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MMP2 — NA
Text-mined interactions from Literome
Ollivier et al., Am J Vet Res 2003
(Corneal Ulcer...) :
We documented that EDTA, doxycycline,
NAC , ilomostat, alpha1PI, and ES
inhibited MMP activity in vitro
Wang et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2006
:
NAC inhibits the expressions of
MMP-2 , MMP-9 in lung fibroblasts
Mizoguchi et al., J Neurochem 2007
:
On the other hand,
MMP-2/-9 inhibitors blocked the METH induced behavioral sensitization and conditioned place preference, a measure of the rewarding effect, and
reduced the METH increased dopamine release in the
NAc
Bogani et al., Biochem Biophys Res Commun 2007
:
MMP-2 activity is directly
inhibited by
NAC and GSH, while LA is ineffective
Mizoguchi et al., J Pharmacol Sci 2008
(Amphetamine-Related Disorders...) :
MMP-2/-9 inhibitors blocked the METH induced behavioral sensitization and conditioned place preference (CPP), a measure of the rewarding effect of a drug, and
reduced the METH increased dopamine release in the
NAc
Voronkina et al., Tsitologiia 2008
(Cell Transformation, Viral) :
NAC action for 2-6 hours completely
inhibited MMP-2 and MMP-9 activity in both cell lines
Popova et al., Antioxid Redox Signal 2010
:
The same effect was achieved by the nontargeted antioxidant Trolox at higher concentration, but the thiol antioxidant
N-acetylcysteine (NAC) inhibited
MMP activity and was not able to induce myofibroblast differentiation
Li et al., Chem Biol Interact 2010
:
DP increased the levels of reactive oxygen species ( ROS ) in HepG2 cells, and antioxidant
N-acetylcysteine (NAC) completely blocked DP-induced ROS accumulation and the disruption of the balance between Bax and Bcl-2 proteins, and effectively
blocked the decreased
MMP and apoptosis, but had no effect on the activation of caspase-8 and the up-regulations of DR4 and DR5 induced by DP
Lu et al., J Atheroscler Thromb 2011
(Plaque, Atherosclerotic) :
Moreover, we found that
NAC down-regulated the expression of VCAM-1,
MMP2 and MMP9, accompanied by inhibition of NF-?B activation and reduced expression of RAGE
Zang et al., Int Immunopharmacol 2013
(Lymphoma, Large B-Cell, Diffuse...) :
Phagocytosis, the loss of
MMP , autophagy and the activated signaling pathways were all
suppressed by ROS scavenger
N-acetyl-l-cysteine (NAC) , HO scavenger catalase or OH scavenger glutathione ( GSH )