◀ Back to TLR2
LEP — TLR2
Text-mined interactions from Literome
Batra et al., Am J Pathol 2007
:
With the present study we evaluated the Toll-like receptor ( TLR ) expression and
TLR ligand-specific activation of murine preadipocytes and adipocytes in the
presence [ wild type ( WT ), 3T3L1 ] or absence of
leptin ( ob/ob ) or leptin signaling ( db/db )
Fortis et al., Salud Publica Mex 2012
(Obesity) :
TLR activation is mediated by fatty acids and their expression is
regulated by
leptin , adiponectin and PPARs
Jaedicke et al., J Leukoc Biol 2013
:
We therefore investigated a possible
role for
leptin in monocyte
TLR and CD14 expression ...
Leptin increased
TLR2 cell-surface and mRNA expression in THP-1 and primary human monocytes ... In conclusion, we show that leptin and LPS differentially influence monocyte phenotype and demonstrate, for the first time, a regulatory
effect of
leptin on the monocyte expression of
TLR2 ...
Leptin stimulated
TLR2 expression may potentiate innate immunity and inflammation in conditions of hyperleptinemia, such as obesity and T2DM
Cha et al., Endocrinology 2013
(Albuminuria...) :
Recent evidence suggests that activation of
Toll-like receptor ( TLR ) signaling induces peripheral insulin resistance and
mediates central insulin and
leptin resistance