Gene interactions and pathways from curated databases and text-mining

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PARP16 — PRKDC

Text-mined interactions from Literome

Ariumi et al., Oncogene 1999 : Thus, DNA-PK suppresses PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes
Veuger et al., Oncogene 2004 : The inhibitory effect of DNA-PK on PARP activity was confirmed in permeabilized cells
Dregalla et al., Aging 2010 (Chromosomal Instability...) : We provide the first evidence for regulation of DNA-PKcs by tankyrase 1 PARP activity and taken together, identify roles of tankyrase 1 with implications not only for DNA repair and telomere biology, but also for cancer and aging
Ruscetti et al., J Biol Chem 1998 : The protein kinase activity of DNA-PK can be stimulated by PARP in the presence of NAD+ in a reaction that is blocked by the PARP inhibitor 1, 5-dihydroxyisoquinoline