Guo et al., Inflammation 2000
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Antisense interleukin-1 (IL-1) receptor associated kinase-2 ( IRAK-2 ) oligonucleotide ( ODN ) and antisense p110 PI 3-kinase ODN blocked IRAK-2 and p110 PI 3-kinase expression, respectively
Lee et al., Invest Ophthalmol Vis Sci 2012
:
Use of specific inhibitor to PI 3-kinase or IRAK demonstrated that IRAK activates PI 3-kinase , the signaling of which phosphorylates IKKa/ß and degrades I?B, subsequently leading to activation of NF-?B