Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of GRB2-PTK2-SOS1
→
PTK2
(increases, GRB2/PTK2/SOS1 Activity)
Giancotti et al., Science 1999 Evidence: FAK also combines with, and may activate, phosphoinositide 3-OH kinase (PI 3-kinase), either directly or through the Src kinase (13). Finally, there is evidence that Src phosphorylates FAK at Tyr925, creating a binding site for the complex of the adapter Grb2 and Ras guanosine 5'-triphosphate exchange factor mSOS (10). These interactions link FAK to signaling pathways that modify the cytoskeleton and activate mitogen-activated protein kinase (MAPK) cascades (Fig. 3A).