Brown et al., J Biol Chem 1999
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No insulin induced activation of PI3K-C2alpha was observed in cell types known to have low responsiveness to insulin including HEK 293 cells, 3T3-L1 preadipocytes, and undifferentiated L5L6 myoblasts ... The mechanism of activation of PI3K-C2alpha by insulin differs from that of class Ia PI 3-kinases in that insulin stimulation did not cause PI3K-C2alpha to associate with IRS-1 or insulin receptor
Ursø et al., FEBS Lett 1999
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Using chimaeric receptor constructs which can be activated independently of endogenous receptors in transfected cells, we found that PI3K-C2alpha activity was stimulated to a greater extent by insulin receptors than IGF receptors in 3T3-L1 adipocytes
Falasca et al., J Biol Chem 2007
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The role of phosphoinositide 3-kinase C2alpha in insulin signaling ... By metabolic labeling, we here identify phosphatidylinositol 3-phosphate as the sole in vivo product of the insulin dependent activation of PI3K-C2alpha , confirming the emerging role of such a phosphoinositide in signaling