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Text-mined interactions from Literome

McNAMARA et al., Exp Eye Res 1999 : LPS extracted from the bacterial culture supernatant was used to demonstrate that upregulation of hBD-2 is caused by LPS
Becker et al., J Biol Chem 2000 : Thus, LPS induction of hBD2 in hTBE cells requires CD14, which may complex with a TLR to ultimately activate NF-kappa B
Tomita et al., Nihon Ronen Igakkai Zasshi 2001 (Klebsiella Infections...) : It has been shown that LPS induced expression of hBD-2 in human tracheobronchial epithelial cells requires CD14, which may complex with Toll-like receptors ( TLRs ) to ultimately activate NF-kappa B
Tsutsumi-Ishii et al., J Leukoc Biol 2002 : Here, we investigated lipopolysaccharide (LPS) mediated transcriptional regulation of the hBD-2 gene by focusing on the roles of NF-kappa B, STAT, and NF-IL-6 sites in mononuclear phagocytes using RAW264.7 cells, which are sensitive to LPS ... In contrast, neither the NF-IL-6 nor STAT binding site was required for LPS induced hBD-2 transcription ... Together, these observations indicate that NF-kappa B plays an important role in the regulation of hBD-2 gene expression in response to LPS
Nitschke et al., Exp Nephrol 2002 : Coincubation of the cultured cells with IL-1alpha or E. coli promote the strongest hbd-2 induction whereas TNF-alpha and LPS lead to a weaker or no ( IL-6 ) hbd-2 induction
Tomita et al., Respirology 2002 : Using a human airway cell line ( LC-2/ad ), lipopolysaccharide (LPS) induced gene expression of hBD-2 was studied in the absence or the presence of ( i ) dexamethasone, ( ii ) inhibition of NF-kappaB and AP-1, ( iii ) intracellular calcium chelator, and ( iv ) cyclooxygenase (COX) inhibitors ... However, COX inhibitors had no effect on LPS induced mRNA expression of hBD-2
Chadebech et al., Cell Biol Toxicol 2003 : Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2 , and hBD-3 expression in response to LPS
Vora et al., J Immunol 2004 : The effect of LPS and peptidoglycan on beta-defensin-2 expression was examined in IEC lines constitutively or transgenically expressing TLRs. Regulation of beta-defensin-2 was assessed using promoter-reporter constructs of the human beta-defensin-2 gene ... In addition, inhibition of Jun kinase prevents up-regulation of beta-defensin-2 protein expression in response to LPS
Mineshiba et al., FEMS Immunol Med Microbiol 2005 : Our results suggest that the two NF-(kappa)B binding sites contribute to LPS mediated hBD-2 transcription while the NF-IL6 binding site represses LPS independent hBD-2 transcription in the HeLa cells
Nagy et al., Microbes Infect 2006 : We found that, in vitro, P. acnes type IA and IB isolates and LPS induced human beta-defensin-2 and proinflammatory cytokine/chemokine expression, and influenced sebocyte viability and differentiation
Chen et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2006 : The expression of hBD-2 gene can be induced by LPS.IL-10 inhibits the inducible expression of hBD-2
Veerayutthwilai et al., Oral Microbiol Immunol 2007 (Dental Caries) : LPS up-regulated IL-1beta, tumor necrosis factor-alpha (TNF-alpha), CCL20, hBD2 , IL-8, TLR2 and TLR4 ; however, Pam3CSK4 down-regulated these mRNAs