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COPS5 — MIF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: O/- complex () → Complex of COPS5-MIF (decreases, COPS5/MIF Activity)
  Evidence: Kleemann et al. [15] provided proof that MIF is taken up by cells and binds to Jab-1, inhibiting the activation of the transcription factor AP-1.
• OpenBEL Selventa BEL large corpus: COPS5 → MIF (decreases) Kleemann et al., Nature 2000*
  Evidence: MIF colocalizes with Jab1 in the cytosol, and both endogenous and exogenously added MIF following endocytosis bind Jab1. MIF inhibits Jab1- and stimulus-enhanced AP-1 activity

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: COPS5 — MIF (direct interaction, two hybrid) Burger-Kentischer et al., FEBS Lett 2005*
• IRef Biogrid Interaction: COPS5 — MIF (direct interaction, pull down) Burger-Kentischer et al., FEBS Lett 2005*
• IRef Biogrid Interaction: COPS5 — MIF (physical association, affinity chromatography technology) Burger-Kentischer et al., FEBS Lett 2005*
• IRef Biogrid Interaction: COPS5 — MIF (physical association, affinity chromatography technology) Kleemann et al., Nature 2000*
• IRef Biogrid Interaction: COPS5 — MIF (direct interaction, pull down) Kleemann et al., Nature 2000*
• IRef Hprd Interaction: COPS5 — MIF (in vitro) Kleemann et al., Nature 2000*
• IRef Hprd Interaction: COPS5 — MIF (two hybrid) Kleemann et al., Nature 2000*
• IRef Hprd Interaction: COPS5 — MIF (in vivo) Kleemann et al., Nature 2000*
• IRef Innatedb Interaction: COPS5 — MIF (unknown, -) Kleemann et al., Nature 2000*
• IRef Intact Interaction: COPS5 — MIF (physical association, two hybrid) Burger-Kentischer et al., FEBS Lett 2005*
• IRef Intact Interaction: COPS5 — MIF (physical association, mass spectrometry studies of complexes) Burger-Kentischer et al., FEBS Lett 2005*
• IRef Intact Interaction: COPS5 — MIF (direct interaction, anti bait coimmunoprecipitation) Burger-Kentischer et al., FEBS Lett 2005*
• IRef Ophid Interaction: COPS5 — MIF (aggregation, confirmational text mining) Kleemann et al., Nature 2000*
• IRef Ophid Interaction: COPS5 — MIF (aggregation, interologs mapping) Brown et al., Bioinformatics 2005