Shaw et al., J Biol Chem 2003
:
Angiotensin II (Ang II) , protein kinase C ( PKC ), reactive oxygen species ( ROS ) generated by NADPH oxidase, the activation of Janus kinase 2 (JAK2) , and the polyol pathway play important parts in the hyperproliferation of vascular smooth muscle cells ( VSMC ), a characteristic feature of diabetic macroangiopathy
Kandalam et al., Regul Pept 2010
:
Ang II increased JAK2 phosphorylation in a time- and dose dependent manner