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PLEKHF1 — TP53
Text-mined interactions from Literome
Oda et al., Cell 2000
(Adenocarcinoma...) :
Through direct cloning of p53 binding sequences from human genomic DNA, we have isolated a novel gene, designated p53AIP1 (
p53 regulated
Apoptosis Inducing Protein 1 ), whose expression is inducible by wild-type p53
Lunghi et al., Blood 2004
(Leukemia, Erythroblastic, Acute) :
Combined treatment results in the induction of the p53AIP1 (
p53 regulated
apoptosis inducing protein 1 ) gene in both cell lines
Lunghi et al., Blood 2006
(Leukemia, Myeloid, Acute) :
Combined treatment resulted in the induction of the proapoptotic p53/p73 target gene p53AIP1 (
p53 regulated
apoptosis inducing protein 1 ) and greatly enhanced the apoptosis of treated cells
Zhao et al., Int J Oncol 2008
(Adenocarcinoma, Papillary...) :
Western blot analysis of apoptosis related proteins demonstrated that treatment with MZ-5-156 ( 10 ( -6 ) M ) for 48 h significantly increased the protein levels of Fas, phospho-p53 ( Ser46 ), p53AIP1 (
p53 regulated
Apoptosis Inducing Protein 1 ), and caspase-8, -9, and -3, and decreased the protein level of Bcl-2
Luedeke et al., PloS one 2012
(Genetic Predisposition to Disease...) :
Prostate cancer susceptibility has previously been associated with truncating germline variants in the gene TP53AIP1 (
tumor protein p53 regulated
apoptosis inducing protein 1 )