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PRODH — TP53

Text-mined interactions from Literome

Maxwell et al., Proc Natl Acad Sci U S A 2000 (Urinary Bladder Neoplasms) : Proline oxidase , a mitochondrial enzyme involved in the proline/pyrroline-5-carboxylate redox cycle, was up-regulated by p53 in ECV but not in DECV cells
Donald et al., Cancer Res 2001 (Colonic Neoplasms) : In the conditionally immortalized murine colonic epithelial cell line YAMC, where the p53 phenotype can be modulated by temperature, proline oxidase expression and ROS production could only be induced when the cells were phenotypically p53 positive
Liu et al., Cancer Res 2009 (Neoplasms) : Proline oxidase (POX) , catalyzing the first step in proline catabolism, is induced by p53 and can regulate cell survival as well as mediate programmed cell death
Phang et al., Annu Rev Nutr 2010 : Matrix metalloproteinases degrading collagen are activated during stress to make proline available, and proline oxidase , the first enzyme in proline degradation, is induced by p53 , peroxisome proliferator activated receptor gamma ( PPARgamma ) and its ligands, and by AMP activated protein kinase downregulating mTOR
Natarajan et al., Free Radic Biol Med 2012 : PRODH expression is inducible by p53 , leading to increased proline oxidation, reactive oxygen species formation, and induction of apoptosis