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BMP4 — PTEN

Text-mined interactions from Literome

Beck et al., Cancer Biol Ther 2007 (Colonic Neoplasms) : BMP induced PTEN suppression was mediated via the RAS/ERK pathway, as pharmacologic inhibition of RAS/ERK, or interference with protein function in the cytosol by DN-RAS prevented BMP induced growth promotion and changes in PTEN levels, as did treatment with noggin, a BMP ligand inhibitor
Mathieu et al., Mol Cell Neurosci 2008 : Silencing Smad5 with siRNA or treatment with Noggin, a BMP antagonist, demonstrated that upregulation of PTEN in NSPCs required BMP/Smad signaling and that this pathway regulated cell cycle exit of NSPCs
Jerde et al., Prostate 2011 : We also treated doxacyclin-inducible PTEN-C4-2B cells with BMP-4 and doxacyclin to determine the effect of BMP on growth and PTEN expression in conditions of increasing PTEN expression ... We found that BMP-4 induces PTEN in E6 and BPH-1 cells and reduces proliferation ... BMP-4 also increased PTEN protein stability ... BMP signaling induces PTEN expression and sustains PTEN protein expression resulting in inhibition of prostate epithelial cell growth