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MAP2K1 — STAT1

Pathways - manually collected, often from reviews:

• NCI Pathway Database IFN-gamma pathway: MEK1 (MAP2K1) → STAT1 (dimer) complex (STAT1) (modification, activates)
  Hu et al., J Biol Chem 2001, Roy et al., Proc Natl Acad Sci U S A 2002
  Evidence: mutant phenotype

Text-mined interactions from Literome

Zhang et al., Carcinogenesis 2004 : In vitro kinase assays using the combined STAT1 proteins as substrates from immunoprecipitation and glutathione S-transferase pull down show that active ERK1, JNK1, p38 kinase, MEK1 and MSK1 stimulated phosphorylation of STAT1 ( Ser727 ) indirectly through an unidentified factor or a downstream kinase
Molnarfi et al., J Immunol 2005 : Although both inhibitors of PI3K and MEK1 diminished the Ser ( 727 ) phosphorylation of STAT1 induced by IFN-beta, only Ly294002 inhibited sIL-1Ra production
Yang et al., Microvasc Res 2009 (AIDS Dementia Complex) : Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase (PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly diminished IL-8-, IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models