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ITIH4 — PTGS2
Text-mined interactions from Literome
Ledeboer et al., Pain 2005
(Hyperesthesia...) :
In contrast, no significant effects of minocycline were observed on
gp120 induced IL-6 and
cyclooxygenase-2 expression in spinal cord or CSF IL-6 levels
Alvarez et al., J Neurochem 2005
(Neuroblastoma) :
Moreover,
gp120 induces
COX-2 promoter transcription ... More importantly, overexpression of NF-kappaB inhibitory subunit, IkappaBalpha, completely abrogated
gp120 induced
COX-2 activity ... However, transfection of p65/relA NF-kappaB was not enough to induce COX-2 transcription, suggesting that NF-kappaB was necessary but not sufficient to control
COX-2 transcription
induced by
gp120 ... Transfection of a dominant negative mutant c-Jun protein, TAM-67, efficiently blocked the
induction of
COX-2 promoter by
gp120 , confirming AP-1 requirement
Alvarez et al., Neuromolecular Med 2007
(Astrocytoma) :
We have investigated the role of
gp120 induced
COX-2 in the astrocytoma human cell line U-87, and the different pathways involved in this activation ... Moreover,
gp120 induces
COX-2 promoter transcription ... In addition, transfection assays with the NF-kappaB inhibitor, IkappaBalpha, prevented
gp120 mediated
COX-2 induction ... The antioxidant pyrrolidine dithiocarbamate inhibited
COX-2 protein expression and COX-2 transcriptional activity
induced by
gp120 ... Thus, our results indicate that
gp120 induced
COX-2 transcription through NF-kappaB activation in astrocytoma cells