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MAPK14 — PLCB3
Pathways - manually collected, often from reviews:
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NCI Pathway Database Endothelins:
ETB receptor/Endothelin-1/Gq/GTP/PLC beta complex (EDNRB-EDN1-GNA11_GNAQ_GNA15_GNA14-PLCB3_PLCB2_PLCB1)
→
p38 alpha (MAPK14)
(modification, activates)
Aquilla et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Badr et al., J Immunol 2005
(HIV Infections) :
Unlike CXCL12, gp120 did not
induce the activation of
phospholipase Cbeta3 and PI3K downstream from CXCR4, whereas p38
MAPK activation was observed
Lo et al., Cell Signal 2006
:
Hematopoietic restrictive Galpha(16) has long been known to stimulate
phospholipase Cbeta ( PLCbeta ) and
induce mitogen activated protein kinase ( MAPK ) phosphorylation
Beekman et al., Cancer Res 1998
(Carcinoma, Small Cell...) :
Expression of catalytically inactive
phospholipase Cbeta disrupts phospholipase Cbeta and
mitogen activated protein kinase signaling and inhibits small cell lung cancer growth