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APOB — CSF2

Text-mined interactions from Literome

Sakai et al., Arterioscler Thromb Vasc Biol 1999 : We have recently demonstrated that oxidized LDL ( Ox-LDL ) has a mitogenic activity for macrophages in vitro in which Ox-LDL induced granulocyte/macrophage colony stimulating factor ( GM-CSF ) production plays an important role ... Ox-LDL induced a significant production of GM-CSF by macrophages, which was effectively inhibited by dexamethasone, prednisolone, and cortisol by 80 %, 65 %, and 50 %, respectively ... Dexamethasone mediated inhibition of Ox-LDL induced GM-CSF mRNA expression and macrophage growth was significantly abrogated by RU-486, a glucocorticoid receptor antagonist ... Our results suggest that the inhibitory effects of glucocorticoids on macrophage growth may be due to the inhibition of Ox-LDL induced GM-CSF production through transactivation of the glucocorticoid receptor
Matsumura et al., J Biol Chem 1999 : Our results suggested that a putative AP-2 binding site from -169 to -160 was a positive responsive element to Ox-LDL and that the NF-kappaB binding site from -91 to -82 was a negative responsive element in Ox-LDL induced GM-CSF transcription
Biwa et al., J Biol Chem 2000 : Ox-LDL induced expression of GM-CSF and its subsequent release were inhibited by calphostin C but not by wortmannin, whereas recombinant GM-CSF induced macrophage proliferation was inhibited by wortmannin by 50 % but not by calphostin C. Ox-LDL activated PI3K at two time points ( 10 min and 4 h ), and the activation at the second but not first point was significantly inhibited by calphostin C and anti-GM-CSF antibody
Kaneko et al., Atherosclerosis 2000 : Moreover, the Ox-LDL induced GM-CSF release from thioglycollate elicited macrophages was significantly higher than that from resident macrophages ... In addition, the Ox-LDL induced thymidine incorporation into macrophages obtained from human group-II PLA(2) transgenic mice and the GM-CSF release from these cells were significantly higher than those from their negative littermates, and the Ox-LDL induced thymidine incorporation into human group-II PLA(2) transgenic macrophages was significantly inhibited by a polyclonal anti-human group-II PLA(2) antibody
Laurenzi et al., Neurochem Res 2001 : Granulocyte/macrophage colony stimulating factor increased the number of process bearing cells, of acetylated LDL binding and of IL-6 secretion induced by LPS
Matsuo et al., Biochem Biophys Res Commun 2004 : Ox-LDL increased GM-CSF release and GM-CSF mRNA expression, and activated GM-CSF gene promoter, all of which were prevented by 15d-PGJ ( 2 ) or 2-cyclopenten-1-one, a cyclopentenone ring of 15d-PGJ ( 2 )
Senokuchi et al., Atherosclerosis 2004 (Arteriosclerosis...) : Ox-LDL induced GM-CSF production was inhibited by MEK1/2 inhibitors but not by p38 MAPK inhibitors in mRNA and protein levels, whereas recombinant GM-CSF induced macrophage proliferation was inhibited by p38 MAPK inhibitors but enhanced by MEK1/2 inhibitors
Senokuchi et al., J Biol Chem 2005 : Statins did not inhibit Ox-LDL induced GM-CSF production, but inhibited GM-CSF induced p38 MAPK activation
Yano et al., Atherosclerosis 2007 : Ox-LDL induced production of GM-CSF was significantly inhibited by troglitazone, but not by ciglitazone ... In conclusion, troglitazone inhibited Ox-LDL induced GM-CSF production by suppressing nuclear translocation of ERK1/2, thereby inhibiting macrophage proliferation
Fuhrman et al., Atherosclerosis 2008 : Ox-LDL induces monocyte-to-macrophage differentiation in vivo : Possible role for the macrophage colony stimulating factor receptor ( M-CSF-R ) ... We thus conclude that Ox-LDL induces monocyte differentiation to macrophages in vivo and this phenomenon involves activation of the M-CSF-receptor
Kinoshita et al., Biochem Biophys Res Commun 2013 (Atherosclerosis) : In mouse peritoneal macrophages, apocynin suppressed the Ox-LDL induced ROS generation, mRNA expression of MCP-1, IL-6 and granulocyte/macrophage colony stimulating factor , and cell proliferation
Rajavashisth et al., Arterioscler Thromb Vasc Biol 1995 : Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL
Pai et al., Kidney Int 1995 : Since atherogenic lipoproteins ( such as low density lipoprotein, LDL ) have been implicated in monocyte migration and proliferation into the glomerular mesangium, we examined the effect of LDL on mesangial cell expression of macrophage colony stimulating factor ( M-CSF ), a cytoregulatory peptide associated with monocyte chemoattraction, differentiation and proliferation
Biwa et al., J Biol Chem 1998 : Ox-LDL as well as phospholipase A2-treated acetylated LDL enhanced mRNA levels and protein release of GM-CSF from macrophages, while neither acetylated LDL nor lysophosphatidylcholine ( lyso-PC ) showed such effects ... The maximal induction of GM-CSF by Ox-LDL was noted at 4 h, followed by a time dependent decrease to a basal level within 24 h. Ox-LDL induced macrophage growth was inhibited by 75 % by replacement of the culture medium at 24 h by a fresh medium containing the same concentration of Ox-LDL, when GM-CSF had already returned to the basal level ... The Ox-LDL induced GM-CSF release was inhibited by calphostin C, a protein kinase C inhibitor, and was significantly reduced in macrophages from the knockout mice lacking class A, type I and type II macrophage scavenger receptors ( MSR-AI/AII )