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NCF1 — RAC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases)
  Rinckel et al., Biochem Biophys Res Commun 1999*
  Evidence: Upon stimulation, a functional NADPH oxidase is assembled when the cytosolic proteins, Rac, p67phox, p47phox, and possibly p40phox, associate with the gp91phox and p22phox transmembrane proteins.
• OpenBEL Selventa BEL large corpus: None → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-RAC1 (increases, Activity)
  
  Evidence: PKC is known to induce cellular reactive oxygen species (ROS) and PKC-dependent activation of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH oxidase has recently been shown to be responsible, in part, for increased oxidative stress in diabetes.
• KEGG Osteoclast differentiation: RAC1 → CYBA/CYBB/NCF1/NCF2/NCF4/NOX1/NOX3 (protein-protein, activation)
  
• KEGG Leukocyte transendothelial migration: RAC1 → Complex of CYBA-CYBB-NCF1-NCF2-NCF4-NOX1-NOX3 (protein-protein, activation)
  
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) (modification, collaborate)
  Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245 complex (NCF1-NCF2-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• NCI Pathway Database RAC1 signaling pathway: p47 Phox/p67 Phox/cytochrome b-245/RAC1/GTP complex (NCF1-NCF2-RAC1-CYBB-CYBA) → RAC1/GTP complex (RAC1) (modification, collaborate) Mizrahi et al., J Biol Chem 2005, Heyworth et al., Mol Biol Cell 1993
  Evidence: physical interaction
• Reactome Reaction: NCF1 → RAC1 (reaction) Ushio-Fukai et al., Circ Res 2002*
• Reactome Reaction: NCF1 → RAC1 (indirect_complex) Ushio-Fukai et al., Circ Res 2002*
• WikiPathways Microglia Pathogen Phagocytosis Pathway: NCF4/NCF2/NCF1 → NCF1/NCF4/NCF2/RAC1/RAC2/RAC3/CYBB/CYBA (mim-conversion)
  
• WikiPathways Microglia Pathogen Phagocytosis Pathway: RAC1/RAC2/RAC3 → NCF1/NCF4/NCF2/RAC1/RAC2/RAC3/CYBB/CYBA (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: NCF1 — RAC1 (two hybrid) Li et al., J Biol Chem 2002, Dorseuil et al., C R Seances Soc Biol Fil 1997*
• IRef Hprd Interaction: NCF1 — RAC1 (in vivo) Li et al., J Biol Chem 2002, Dorseuil et al., C R Seances Soc Biol Fil 1997*
• IRef Hprd Interaction: NCF1 — RAC1 (in vitro) Li et al., J Biol Chem 2002, Dorseuil et al., C R Seances Soc Biol Fil 1997*
• IRef Ophid Interaction: RAC1 — NCF1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: RAC1 — NCF1 (aggregation, confirmational text mining) Dorseuil et al., C R Seances Soc Biol Fil 1997*

Text-mined interactions from Literome

Robinson et al., Histochem Cell Biol 2004 : X-ray crystallography and NMR spectroscopy have provided detailed structural data on these domains and how p47-phox and p67-phox interact with p22-phox and activated Rac , respectively
Kim et al., J Leukoc Biol 2006 : Membrane translocation of p47phox and p67phox as well as Rac1 activation was not increased further by combined PMA and AA stimulation
Choi et al., Int Immunopharmacol 2006 : Translocation of p47(phox), p67(phox) and Rac was increased in response to PMA, and Tau-Cl inhibited the PMA stimulated translocation of p47(phox) and p67(phox) to plasma membrane without affecting the translocation of Rac
Usatyuk et al., J Biol Chem 2009 (Hyperoxia) : Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia induced p47phox translocation and reactive oxygen species generation in lung endothelial cells