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IFI27 — TP53
Text-mined interactions from Literome
Pei et al., Clin Cancer Res 2004
(Multiple Myeloma) :
These events were associated with nuclear factor kappaB inactivation, c-Jun NH ( 2 ) -terminal kinase activation,
p53 induction , and caspase dependent cleavage of p21 ( CIP1 ),
p27 ( KIP1 ), and Bcl-2, as well as Mcl-1, X-linked inhibitor of apoptosis, and cyclin D1 down-regulation
Lee et al., Head Neck 2004
(Carcinoma, Squamous Cell...) :
Overexpression of
p53 markedly downregulated the transcription of COX-2, but the overexpression of
p27 did not
affect COX-2 levels in HNSCC cell lines
Choi et al., J Nutr Biochem 2009
(Breast Neoplasms) :
In an additional study, apigenin also
increased the accumulation of
p53 and further enhanced the level of p21 ( Cip1 ), with no change in
p27 ( Kip1 )
Song et al., Mol Cancer Res 2008
:
Expression of an IFN-inducible cellular senescence gene,
IFI16 , is
up-regulated by
p53
Samba-Louaka et al., Infect Immun 2009
:
Increases of p21 and
p27 levels are
independent of
p53 transcriptional induction and result from protein stabilization through inhibition of the ubiquitin/proteasome degradation pathway
Ikari et al., J Cell Biochem 2011
:
Together, lack of magnesium may increase p21 ( Cip1 ) and
p27 ( Kip1 ) levels
mediated by the decrease in ATP content and the activation of
p53 , resulting in the suppression of cell cycle progression from G1 to S phase in NRK-52E cells