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CCND1 — PTHLH
Text-mined interactions from Literome
Beier et al., Mol Endocrinol 2002
(Exostoses, Multiple Hereditary) :
Here we demonstrate that JMC mutations of the
PTH/PTHrP receptor induce
activation of the
cyclin D1 and cyclin A promoters in primary mouse chondrocytes and rat chondrosarcoma cells
Datta et al., J Bone Miner Res 2005
(MAP Kinase Signaling System) :
PTHrP inhibited
cyclin D1 protein expression 7-fold in a dose- and time dependent manner and increased the level of p16 protein in differentiated osteoblasts ... Additionally,
PTHrP reduced
cyclin D1-CDK4/CDK6 and CDK1 kinase activities ... H-89, a PKA inhibitor, did not alter the
effect of
PTHrP on
cyclin D1 , suggesting a PKA independent mechanism ...
PTHrP upregulates JunB and
reduces cyclin D1 expression while inducing G1 cell cycle arrest in differentiated osteoblasts
Datta et al., J Bone Miner Res 2007
:
PTHrP induced a proliferative
cyclin D1 activation in low-density osteoblastic cells ... These data indicate that PTH and
PTHrP induce
cyclin D1 expression in early osteoblastic cells and their action is developmental stage specific