Gene interactions and pathways from curated databases and text-mining

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ARSK — TRAF6

Text-mined interactions from Literome

Noguchi et al., J Biol Chem 2005 : Consistent with our previous findings that TRAF2 and TRAF6 activate ASK1, H ( 2 ) O ( 2 ) -induced ASK1 activation and cell death were strongly reduced in the cells derived from Traf2-/- and Traf6-/- mice
Fujino et al., Mol Cell Biol 2007 : However, the precise mechanisms by which Trx inhibits and TRAF2 and TRAF6 activate ASK1 have not been elucidated fully ... These findings demonstrate that Trx, TRAF2 , and TRAF6 regulate ASK1 activity by modulating N-terminal homophilic interaction of ASK1
Yuk et al., Immunol Cell Biol 2009 (Tuberculosis) : Furthermore, we present evidence that TNF receptor associated factor (TRAF) 6 activities were essential for ROS mediated ASK1 activation by M. bovis BCG
Nishitoh et al., Mol Cell 1998 : Here we show that ASK1 interacts with members of the TRAF family and is activated by TRAF2, TRAF5, and TRAF6 overexpression