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HMGB1 — IL6

Text-mined interactions from Literome

Taniguchi et al., Arthritis Rheum 2003 (Arthritis, Rheumatoid...) : SFMs expressed RAGE and released TNFalpha, interleukin-1beta (IL-1beta), and IL-6 upon stimulation with HMGB-1
Ivanov et al., Blood 2007 : Loss of HMGB1 leads to a defect in the IL-6 , IL-12, TNFalpha, and iNOS response to CpG-ODN
Bidwell et al., J Cell Biochem 2008 (Bone Resorption) : Extracellular HMGB1 enhances the expression of RANKL, TNFalpha, and IL6 in osteoblastogenic bone marrow stromal cell cultures, and it is chemotactic to osteoclasts
Pullerits et al., Arthritis Res Ther 2008 (Arthritis, Experimental) : No significant differences were detected between spleen cells from TNFalpha+/+ mice versus TNFalpha-/- mice regarding IL-6 production upon stimulation with highly purified HMGB1 after 24 hours and 48 hours
Hasegawa et al., Kokubyo Gakkai Zasshi 2008 (Periodontitis) : In conclusion, PDL cells produce IL-6 and IL-11 in response to HMGB1 via RAGE, TLR2 and TLR4
Zhang et al., Nan Fang Yi Ke Da Xue Xue Bao 2008 : [ Effect of progesterone on high mobility group Box-1 protein induced interleukin-6 release by human umbilic vein endothelial cells ] ... Progesterone can dose-dependently inhibit HMGB1 induced IL-6 release from HUVECs, suggesting the protective role of progesterone in endotoxemia
Kamau et al., J Gen Virol 2009 : HMGB1 regulated tumour necrosis factor alpha, interleukin (IL)-6 , IL-8 and alpha interferon secretion in DENV infected DCs
Loppnow et al., J Cell Mol Med 2011 : In this atherosclerosis related inflammatory model LPS ( lipopolysaccharide, endotoxin ), as well as high mobility group box 1 stimulation resulted in synergistic ( i.e. over-additive ) IL-6 ( interleukin-6 ) production as measured in ELISA
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6 , IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed ... In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6 , IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Lynch et al., Am J Nephrol 2010 : HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has putative intracellular signalling effects regulating the production of interleukin-1 and tumour necrosis factor in a number of inflammatory conditions
Hou et al., J Cell Physiol 2011 : HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src, Akt and NF-?B pathways ... In this study, we investigated the intracellular signaling pathway involved in HMGB-1 induced IL-6 production in human synovial fibroblast cells ... HMGB-1 caused concentration- and time dependent increases in IL-6 production ... HMGB-1 mediated IL-6 production was attenuated by receptor for advanced glycation end products ( RAGE ) monoclonal antibody ( Ab ) or siRNA
Wähämaa et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid...) : Stimulation with HMGB1 in complex with LPS, IL-1a or IL-1ß enhanced production of TNF, IL-6 and IL-8
Carbone et al., Clin Cancer Res 2012 (Cell Transformation, Neoplastic...) : HMGB1 and Nalp3 induce proinflammatory responses and lead to interleukin-1ß and TNF-a secretion and NF-?B activity, thereby promoting cell survival and tumor growth
Weng et al., Shock 2012 (Acute Disease...) : Honokiol significantly reduced the increases in serum tumor necrosis factor-a, interleukin 1, and nitric oxide levels 3 h and serum high-mobility group box 1 24 h after acute pancreatitis induction
Kanaan et al., Innate Immun 2013 (Chronic Disease...) : TNF-a, regulated by miR-155 and miR-146a, was decreased in the LPS pretreated group at all time points ( P? < ?0.05 ), as were HMGB1 , a key alarmin regulated by miR-146, -142-3p, -299 and -200c ( P? < ?0.05 ), and IL-1ß and IL-6 , both regulated by miR-132and miR-21 respectively ( P? < ?0.05 )
Zhou et al., J Neuroimmunol 2013 (MAP Kinase Signaling System) : Our results demonstrate for the first time that NPY can directly induce active HMGB1 release and cytoplasmic translocation, while the production of TNF-a, IL-1ß and IL-6 is not affected
Davalos et al., J Cell Biol 2013 (Inflammation) : HMGB1 depletion, HMGB1 blocking antibody, or TLR-4 inhibition attenuated senescence associated IL-6 secretion, and exogenous HMGB1 stimulated NF-?B activity and restored IL-6 secretion to HMGB1 depleted cells