Kietzmann et al., Thromb Haemost 2003
(Anoxia...) :
However, the role of MAPKs and PKB in HIF-1 mediated PAI-1 regulation is not clear
Görlach et al., Thromb Haemost 2003
(Anoxia) :
Reactive oxygen species modulate HIF-1 mediated PAI-1 expression : involvement of the GTPase Rac1 ... However, the role of ROS in HIF-1 mediated regulation of PAI-1 is not clear
Dimova et al., Ann N Y Acad Sci 2006
(Carcinoma, Hepatocellular...) :
The MAPK pathway and HIF-1 are involved in the induction of the human PAI-1 gene expression by insulin in the human hepatoma cell line HepG2
Diebold et al., Thromb Haemost 2008
:
In the presence of RacT17N thrombin induced PAI-1 promoter activity was abrogated whereas RacG12V increased PAI-1 promoter activity, and this response was essentially dependent on the transcription factor hypoxia-inducible factor-1 (HIF-1) ... Finally, upregulation of PAI-1 by Rac-1 and HIF-1 was essential for thrombin stimulated proliferation of PASMC ... These findings indicate that Rac-1 is an important mediator of thrombin signaling and may contribute to pulmonary vascular remodeling via HIF-1 dependent upregulation of PAI-1 leading to enhanced proliferation of PASMC