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CASP3 — FLT3

Text-mined interactions from Literome

Fukuda et al., Blood 2009 (Acute Disease...) : ITD-Flt3 dramatically increased the number of primary mouse marrow c-kit ( + ), Sca-1 ( + ), Lin ( Neg ) cells and colony forming unit granulocyte-macrophages ( CFU-GMs ) able to proliferate in the absence of growth factors, whereas Survivin deletion significantly reduced growth factor independent proliferation and increased apoptosis, which was further accentuated by SU5416
Pietschmann et al., Mol Cancer Ther 2012 (Leukemia, Myeloid, Acute) : Here, we show that activated caspase-3 also contributes to the degradation of FLT3-ITD and that STAT5 is a direct target of this protease