Gene interactions and pathways from curated databases and text-mining

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CREB3 — EGFR

Text-mined interactions from Literome

Tokunou et al., Arterioscler Thromb Vasc Biol 2001 : Inhibition of the epidermal growth factor receptor by AG1478 also inhibited the thrombin induced CREB phosphorylation
Funakoshi et al., J Biol Chem 2002 : Inhibition of epidermal growth factor-receptor by AG1478 suppressed the AngII induced CREB phosphorylation as well as activation of ERK and p38MAPK
Fukuyama et al., Biochem Biophys Res Commun 2005 (Hypertrophy) : Inhibition of epidermal growth factor receptor (EGFR) and mitogen- and stress activated protein kinase-1 also suppressed PGF ( 2alpha ) -induced CREB phosphorylation
Pham et al., J Cell Physiol 2008 : The p38 ( MAPK ) selective inhibitor, SB202190, but not the MEK selective inhibitor, PD98059, or the EGFR kinase inhibitor, AG1478, inhibited Ang II-dependent COX-2 expression and CREB phosphorylation
Yeh et al., Differentiation 2012 : Together, these results demonstrate that ß-adrenergic stimulation activates diverse cell survival and progrowth signaling pathways, including cAMP and EGFR linked activation of ERK1/2, p38MAPK, and p70S6K, and also induction of ß2-ARs, possibly mediated by CREB and NF-?B, resulting in salivary gland enlargement