Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of ITGAV-ITGB5
→
VEGFA
(increases, VEGFA Activity)
Evidence: VEGF enhanced cell adhesion, migration, soluble ligand binding, and adenovirus gene transfer mediated by alphavbeta3 and also activated other integrins, alphavbeta5, alpha5beta1, and alpha2beta1, involved in angiogenesis. The major findings of our studies are as follows. First, VEGF165 can activate integrin aVb3, leading to enhanced adhesion of endothelial cells to a variety of ligands.
OpenBEL Selventa BEL large corpus:
Complex of ITGAV-ITGB5
→
VEGFA
(increases, VEGFA Activity)
Evidence: Fifth, VEGF165 activation is not targeted to a single integrin; b1 integrins, as exemplified by a5b1 and a2b1, also are affected by VEGF165 stimulation. In addition, our data suggest that aVb5 can be activated by the growth factor.