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CREB3 — EGR1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Greenwood et al., J Neurochem 2002
(Neuroblastoma) :
The levels of both EGR1 and phosphorylated CREB ( pCREB ) slowly decayed over 4-8 h.
CREB phosphorylation and
EGR1 induction showed similar sensitivity to carbachol concentration, with EC ( 50 ) values in the range of 1-10 microM, and the changes in both transcription factors were blocked by the muscarinic antagonist atropine ... As both
CREB phosphorylation and
EGR1 induction have been linked to long-term potentiation and some forms of memory consolidation, these results may implicate CREB and EGR1 in independent or partially independent cholinergic signalling pathways involved in memory processes
Liu et al., Brain Res Mol Brain Res 2005
:
In contrast, there were no significant changes in
CREB phosphorylation or
Egr1 induction
Hao et al., J Biol Chem 2008
(Atherosclerosis...) :
Our data also imply that
CREB , a downstream component of the ERK pathway,
regulates Egr-1 expression in HAECs
Pradines et al., Cell Signal 2008
:
Whatever the differentiation state of 1C11 cells, the PrP ( C ) -dependent
CREB activation
triggers Egr-1 and c-fos transcription, two immediate early genes that relay CREB 's role in cell survival and proliferation as well as in neuronal plasticity
Mayer et al., Eur J Cell Biol 2009
(Insulinoma) :
Together, these data indicate that stimulus induced transcription of the
Egr-1 gene in beta-cells
requires combinatorial regulation by Elk-1 and
CREB following activation of ERK
Mayer et al., J Cell Biochem 2008
:
Elk-1,
CREB , and MKP-1
regulate Egr-1 expression in gonadotropin releasing hormone stimulated gonadotrophs ... Expression of a dominant negative mutant of
CREB reduced GnRH receptor induced upregulation of
Egr-1 expression, indicating that CREB plays a role in the signaling pathway that regulates Egr-1 expression in gonadotrophs