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CAPN1 — MMP2
Text-mined interactions from Literome
Jiang et al., PloS one 2008
:
Calpain-1 activation is
required for
MMP2 expression in fibroblasts and is induced in cardiomyocytes by Ang II
Li et al., Diabetes 2011
(Cardiomyopathy, Hypertrophic...) :
In cultured cardiac fibroblasts, high glucose induced proliferation and
MMP activities were
prevented by
calpain inhibition
Subramanian et al., J Cardiovasc Pharmacol 2012
(Aortic Aneurysm, Abdominal...) :
Inhibition of
calpain , a calcium activated neutral cysteine protease, by overexpression of its endogenous inhibitor, calpastatin,
attenuates AngII induced leukocyte infiltration, perivascular inflammation, and
MMP activation in mice
Singh et al., Can J Physiol Pharmacol 2012
(Anoxia...) :
On the other hand, inhibition of
calpain activity upon treatment with leupeptin or MDL 28170 significantly
reduced the
MMP activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity
Jiang et al., Hypertension 2012
(Calcinosis...) :
Calpain-1 regulation of
matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age associated aortic wall calcification and fibrosis ... However, the
role of
calpain-1 in
MMP2 activation and extracellular matrix remodeling remains unknown