◀ Back to TP53

SUB1 — TP53

Text-mined interactions from Literome

Bothner et al., J Mol Biol 2001 : In response to hyperproliferative signals, p14(Arf) stabilizes p53 by binding to Hdm2 and inhibits the ubiquitination and subsequent proteosome dependent degradation of p53
Sánchez-Aguilera et al., Blood 2002 (Lymphoma...) : p14(ARF) , the alternative product from the human INK4a/ARF locus, antagonizes Hdm2 and mediates p53 activation in response to oncogenic stimuli
Piboonniyom et al., Oral Oncol 2002 (Carcinoma, Squamous Cell...) : This locus encodes two partially overlapping genes, the cdk inhibitor p16(ink4a), and p14(ARF) , an inhibitor of mdm2 mediated degradation of p53
Park et al., Cancer Genet Cytogenet 2002 (Bone Neoplasms...) : p53 only did not suppress the growth of MG63 either ; however, coexpression of p14(ARF) with p53 increased the fraction of the G0/G1 phase in MG63 cells
Tango et al., Hum Gene Ther 2002 (Carcinoma, Non-Small-Cell Lung...) : p14(ARF) , a product of the INK4A/ARF locus, induces p53 upregulation by neutralizing the effects of MDM2, a transcriptional target of p53 that antagonizes its function ... Here we report that adenovirus mediated p14(ARF) gene transfer leads to the accumulation of ectopically transduced p53 and to apoptosis in human cancer cells
Deng et al., Biochem Biophys Res Commun 2002 (Breast Neoplasms) : Adp14 ( ARF ) -mediated expression of p14(ARF) also resulted in a considerable increase in the amounts of p53 and its target proteins, p21 ( WAF1 ) and MDM2
Shamanin et al., Mol Cell Biol 2004 (Cell Transformation, Neoplastic) : Hence, p53 degradation and inhibition of p14(ARF) signaling to p53 are independent functions of HPV16 E6
Watanabe et al., Int J Gynecol Pathol 2004 (Carcinoma, Endometrioid...) : p14 activates p53 by inhibiting MDM2 expression and arrests the cell cycle in G1 and G2/M. Abnormal p14 expression has been reported in various human cancers
Shikami et al., Leuk Res 2006 (Leukemia, Myeloid, Acute...) : Since p14(ARF) has been demonstrated to inhibit p53 degradation by binding to MDM2, repression of p14(ARF) expression in t ( 8 ; 21 ) AML may facilitate the degradation of p53 by MDM2
Hopkins-Donaldson et al., Neoplasia (New York, N.Y.) 2006 (Mesothelioma...) : Malignant pleural mesotheliomas ( MPMs ) are usually wild type for the p53 gene but contain homozygous deletions in the INK4A locus that encodes p14(ARF) , an inhibitor of p53-MDM2 interaction
Chang et al., Oncogene 2007 (Neoplasms) : Although p16(INK4a) is a critical component in retinoblastoma protein ( Rb ) -mediated growth regulatory pathway, p14(ARF) plays a pivotal role in the activation of p53 upon oncogenic stress signals
Lin et al., Oncogene 2007 (Burkitt Lymphoma...) : Both p16(INK4A) and p14(ARF) are capable of inhibiting the cell-cycle progression, albeit in different manner ; p16(INK4A) is phosphorylation of retinoblastoma (pRB) dependent while p14(ARF) is p53 dependent
Kishore et al., Biochem J 2007 : Furthermore, PC4 enhances p53 recruitment to the PC4 promoter
Williams et al., Cold Spring Harb Symp Quant Biol 2008 (Disease Models, Animal...) : A master regulator of Rb and p53 is the INK4-ARF ( CDKN2A/B ) locus that encodes two CDK inhibitors, p16(INK4A) and p15(INK4B), that maintain Rb in its active, hypophosphorylated form, and p14(ARF) ( p19(Arf) in mice ), that inhibits Mdm2 and activates p53
Chen et al., J Biol Chem 2012 (Lymphoma, B-Cell) : Transforming growth factor ß1 ( TGF-ß1 ) suppresses growth of B-cell lymphoma cells by p14(ARF) dependent regulation of mutant p53 ... Overexpression of p14(ARF) blocked the down-regulation of mutant p53 and prevented growth arrest
Love et al., Cell cycle (Georgetown, Tex.) 2012 : PCAF was required for the transcriptional activation of p21 in response to exogenous p53 in p53-null cells, nutlin-3, DNA damaging agents and p14(ARF) expression, suggesting a broad requirement for PCAF in p53 signaling to p21 after stress
van Leeuwen et al., Mol Cancer Ther 2013 : Here, we show that p14(ARF) increases the level of p53 acetylated at lysine 382 in a nuclear chromatin-rich fraction
Stott et al., EMBO J 1998 : Conversely, p53 negatively regulates p14(ARF) expression and there is an inverse correlation between p14(ARF) expression and p53 function in human tumour cell lines