Gene interactions and pathways from curated databases and text-mining

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CSRP1 — IL8

Text-mined interactions from Literome

Devaraj et al., J Mol Cell Cardiol 2004 (Arteriosclerosis) : Furthermore, CRP upregulated NF-kappa B activity in HAEC and inhibitors of NF-kappa B significantly reversed the upregulation of IL-8 by CRP
Kibayashi et al., Clin Sci (Lond) 2005 (Arteriosclerosis) : In the present study, we examined the effect of pitavastatin ( NK-104 ), a synthetic statin ( 3-hydroxy-3-methylglutaryl CoA reductase inhibitor ), on IL-8 production induced by CRP in human AoEC ( aortic endothelial cells )
Singh et al., Arterioscler Thromb Vasc Biol 2006 : Also, CRP alone increased secretion of IL-8 , IL-6, and tumor necrosis factor from HMDMs and did not inhibit LPS induced secretion of these cytokines
Wang et al., Exp Eye Res 2010 : Neutralization of Fc gamma receptors by anti-CD32 and CD64 antibodies produced 39.9+/-1.6 and 59.5+/-2.6 % reduction, respectively, of CRP stimulated IL-8 secretion, whereas that by anti-CD16 antibody had no effect
Heuertz et al., J Immunol 1996 (Lung Diseases, Interstitial) : CRP inhibits chemotaxis of complement ( C5a ) -, LTB4-, IL-8- , and FMLP stimulated neutrophils in vitro, and rabbits and transgenic mice with elevated serum CRP levels exhibit diminished neutrophil infiltration and vascular permeability in models of chemotactic factor induced alveolitis