Chen et al., Nucleic Acids Res 2003
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Time course luciferase assays and time course gel mobility shift assays reveal that the Smad3/4 complex is largely responsible for the immediate response of the SM22alpha promoter to TGF-beta induction, and also contributes to the maximal promoter activity
Qiu et al., Biochem Biophys Res Commun 2006
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Dynamic changes in chromatin acetylation and the expression of histone acetyltransferases and histone deacetylases regulate the SM22alpha transcription in response to Smad3 mediated TGFbeta1 signaling
Kennard et al., J Biol Chem 2008
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Furthermore, the Hes1 repressor protein augmented Smad3 transactivation of the SM22alpha promoter