◀ Back to IL5
CD28 — IL5
Text-mined interactions from Literome
Umland et al., Am J Respir Cell Mol Biol 1999
(Hypersensitivity...) :
Of the cytokine mRNAs examined in the lungs of CSA pretreated, antigen challenged mice, IL-5 mRNA levels were the least reduced, paralleling the resistance of IL-5 to CSA observed in vitro and suggesting a
role for
CD28 in the in vivo induction of
IL-5
Staples et al., Biochem Biophys Res Commun 2000
:
By contrast, IL-10 totally inhibited CD3 +
CD28 induced
IL-5 release and inhibited mRNA by 50-60 %
Verbon et al., Antimicrob Agents Chemother 2000
:
In all six volunteers ingestion of thalidomide was associated with enhanced SEB- and
anti-CD3/CD28 induced production of the Th1 cytokine gamma interferon ( P < 0.05 ) and a decrease in the level of anti-CD3/CD28 induced
interleukin-5 (IL-5) production ( P < 0.05 )
Okkenhaug et al., Nat Immunol 2001
:
Nonetheless, this mutated form of
CD28 still prevents the induction of anergy and
promotes T cell proliferation,
interleukin 2 secretion and B cell help
Lordan et al., J Allergy Clin Immunol 2001
(Asthma) :
These data suggest that
IL-5 production in the airways of subjects with moderately severe asthma is largely
independent of
CD28 mediated costimulation
Marin et al., Exp Hematol 2007
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
Moreover, the presence of 4-1BB or
CD28 in the receptor
increased the production of interleukin (IL)-2, tumor necrosis factor (TNF)-alpha, TNF-beta,
IL-5 , IL-6, and IL-8 elicited by coculture with ALL cells
Koch et al., Clin Immunol 2007
(Asthma) :
There was an increased
anti-CD3/anti-CD28 induced
IL-5 expression in T cells of asthmatics compared with normals ( p < 0.01 )
Abreu et al., Arthritis Res Ther 2010
(Arthritis, Experimental...) :
Ex vivo, Rac1 inhibitory peptide suppressed T-cell
receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and
interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Smeets et al., BMC immunology 2012
:
Translation towards a primary, whole blood setting and purified human CD4+ T cells revealed that PMA/CD3 stimulation induced a more pronounced Th1 specific, Lck and PKC? dependent IFN? production, whereas
PMA/CD28 induced Th2 specific
IL-5 and IL-13 production, independent of Lck activation
Dumont et al., J Immunol 1998
:
PD98059 inhibited TNF-alpha, IL-3, granulocyte-macrophage (GM)-CSF, IFN-gamma, and to a lesser extent IL-6 and IL-10 production but enhanced IL-4,
IL-5 , and IL-13 production
induced by CD3/PMA or
CD3/CD28