Gene interactions and pathways from curated databases and text-mining

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CD46 — INS

Text-mined interactions from Literome

Sell et al., Endocrinology 2006 (Inflammation) : Among these candidates, MCP-1 alone impaired insulin signaling in skeletal muscle cells at doses similar to its physiological plasma concentrations ( 200 pg/ml ), whereas IL-6, IL-8, and macrophage inflammatory protein-1beta were effective at very high concentrations only
Bennett et al., Diabetes 1997 : Insulin , the primary substrate for IDE, inhibits the proteolytic activity of the IDE-MCP complex but not of purified MCP
Hamel et al., Endocrinology 1998 : Inhibitors of IDE also blocked the insulin effect on MCP activity, as did treatment with SDS