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IRF6 — RAC2

Text-mined interactions from Literome

Patel et al., J Surg Res 2004 : We have shown that lipopolysaccharide (LPS) stimulation leads to Rac activation in THP-1 cells
Kamon et al., EMBO J 2006 : LPS increased the activity of RhoB, but not of RhoA, Cdc42, or Rac1/2 in a manor dependent on LPS-TRIF- but not LPS-Myd88 signaling
Miletic et al., Blood 2007 (Granulomatous Disease, Chronic...) : Here, we identify the Vav family of Rho guanine nucleotide exchange factors ( GEFs ) as critical mediators of LPS induced MyD88 dependent activation of Rac2 , NADPH oxidase, and ROI production using mice deficient in Vav1, Vav2, and Vav3
Yao et al., Biochim Biophys Acta 2011 (Lung Injury) : LPS activated both Rac1 and Rac2 , but not CDC42 or RhoA activities in lungs, and specific inhibition of Rac activities by NSC23766 effectively alleviated LPS induced injury