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Zacharowski et al., Arterioscler Thromb Vasc Biol 2000
(Myocardial Infarction...) :
LPS also
caused an upregulation of the expression of intercellular adhesion molecule-1 and
P-selectin , whereas LTA downregulated these molecules and attenuated the accumulation of polymorphonuclear granulocytes caused by myocardial ischemia/reperfusion
Cerwinka et al., Shock 2001
(Hypercholesterolemia) :
However, hypercholesterolemia enhanced
LPS induced expression of
P-selectin , E-selectin, and ICAM-1 in several vascular beds, while VCAM-1 expression was unaffected ... Thrombocytopenia, induced with anti-platelet serum, did not alter
LPS induced
P-selectin expression in either group, suggesting that platelets do not contribute to this response
Andonegui et al., J Immunol 2002
:
The results revealed a 20- to 50-fold increase in
P-selectin expression in
response to
LPS in all wild-type tissues examined but no response in any TLR4 ( d ) tissues ... Surprisingly, there was consistently a partial, significant increase in P-selectin expression in numerous microvasculatures including skin and pancreas, but no increase in
P-selectin was detected in lung, muscle, and other organs in CD14 ( -/- ) mice in
response to
LPS
Andonegui et al., Blood 2005
(Inflammation...) :
Here we demonstrate that although platelets do not increase
P-selectin expression in
response to
LPS , platelets bind more avidly to fibrinogen under flow conditions in a Toll-like receptor-4 (TLR4) dependent manner
Buenestado et al., JPEN J Parenter Enteral Nutr 2006
:
Immunohistochemistry showed
LPS induced increase in
P-selectin expression attenuated by LCT and LCT-MCT but not LCT-MUFA
Kadl et al., Arthritis Rheum 2009
(Inflammation...) :
LPS , but not OxPAPC,
induced the expression of adhesion molecules E-selectin,
P-selectin , intercellular adhesion molecule 1, and vascular cell adhesion molecule 1
Ma et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009
:
It may involve in platelet activation as an important mediator of
LPS induced
CD62P and CD40L expressions on platelets
Coughlan et al., J Exp Med 1994
(Neutropenia) :
We report in vivo studies in which intravenous administration of lipopolysaccharide (LPS) to anesthetized rats caused a very rapid onset ( < 5 min ) of neutropenia, in association with induction of surface expression of P-selectin on microvascular endothelial cells in kidney, liver and lung ; analogous induction of
P-selectin expression by cultured endothelial cells was observed in
response to
LPS stimulation in vitro
Eppihimer et al., Circ Res 1996
:
LPS induced upregulation of
P-selectin was greatest in heart and stomach, which exhibited insignificant constitutive expression of P-selectin
Pan et al., J Biol Chem 1998
:
Tumor necrosis factor-alpha (TNF-alpha) or
lipopolysaccharide (LPS) increases synthesis of
P-selectin in murine but not in human endothelial cells
Pan et al., J Biol Chem 1998
:
Tumor necrosis factor-alpha (TNF-alpha) or
lipopolysaccharide (LPS) increases expression of the
P-selectin gene in murine, but not in human, endothelial cells ... The presence of these elements in the murine, but not the human, P-selectin gene may explain in part why TNF-alpha or
LPS stimulates transcription of
P-selectin in a species-specific manner