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APC — NFKBIA

Text-mined interactions from Literome

Takehana et al., Biochem Biophys Res Commun 2002 : Despite having a strong inhibitory effect on the NF-kappaB dependent transcriptional activation, APC0576 does not inhibit the IL-1 induced DNA binding of NF-kappaB, degradation of I-kappaB-alpha , or phosphorylation of RelA ( p65 )
Yuksel et al., Thromb Haemost 2002 (MAP Kinase Signaling System...) : APC inhibited both the binding of nuclear factor-kappa B (NF-kappa B) to target sites and the degradation of I kappa B alpha
Lu et al., Am J Physiol Heart Circ Physiol 2009 (Myocardial Reperfusion Injury) : APC resulted in ROS dependent phosphorylation of IkappaBalpha and activation of NF-kappaB before I/R. APC also increased the expression of Bcl-2 before I/R