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BDNF — FOXO3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mai et al., J Neurochem 2002
(Neuroblastoma) :
BDNF increased the phosphorylation of the forkhead transcription factor
FKHRL1 through activation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, and the phosphorylation of the cyclic AMP response element binding protein ( CREB ) through activation of extracellular signal regulated kinase1/2 ( ERK1/2 ) ... Overexpression of GSK3beta did not affect
BDNF induced phosphorylation of Akt, ERK1/2, or
FKHRL1 , but abolished CREB phosphorylation induced by BDNF
Zhu et al., Brain Res Mol Brain Res 2004
(Neuroblastoma) :
Regulation of
FOXO3a by
brain derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells ... In the present study, we examined the
regulation of
FOXO3a by
brain derived neurotrophic factor (BDNF) in retinoic acid ( RA ) -differentiated human SH-SY5Y neuroblastoma cells ...
BDNF caused a rapid and time dependent decrease of nuclear
FOXO3a with a corresponding increase of cytosolic FOXO3a ... The regulatory
effect of
BDNF on
FOXO3a and its target genes may play a significant role in the BDNF mediated neuronal survival, differentiation, and plasticity