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EGFR — ESR1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
ESR1
—
EGFR
(physical association, affinity chromatography technology)
Hitosugi et al., J Biol Chem 2007*
-
IRef Hprd Interaction:
ESR1
—
EGFR
(in vitro)
Márquez et al., Endocrine 2001*
-
IRef Intact Interaction:
Complex of SRC-EGFR-ESR1
(association, anti bait coimmunoprecipitation)
Hitosugi et al., J Biol Chem 2007*
-
IRef Intact Interaction:
ESR1
—
EGFR
(physical association, anti tag coimmunoprecipitation)
Zhang et al., Oncogene 2011*
-
IRef Intact Interaction:
ESR1
—
EGFR
(physical association, anti bait coimmunoprecipitation)
Zhang et al., Oncogene 2011*
-
IRef Intact Interaction:
ESR1
—
EGFR
(physical association, anti bait coimmunoprecipitation)
Hitosugi et al., J Biol Chem 2007*
-
IRef Ophid Interaction:
ESR1
—
EGFR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
ESR1
—
EGFR
(aggregation, confirmational text mining)
Márquez et al., Endocrine 2001*
Text-mined interactions from Literome
Stoica et al., Oncogene 2003
:
Experiments employing selective ErbB inhibitors demonstrate that the effect of HRG-beta1 on
ER-alpha expression and activity is also
mediated by ErbB2 and not by
EGFR , demonstrating that ErbB2 is the primary mediator of the effects of HRG-beta1 on ER-alpha regulation
Stoica et al., Oncogene 2003
(Breast Neoplasms) :
Experiments employing selective ErbB inhibitors demonstrate that the effect of estradiol on
ER-alpha expression and activity is
mediated by ErbB2 and not by
EGFR
Johnston et al., Clin Cancer Res 2006
(Breast Neoplasms) :
The increasing recognition of the
roles of
epidermal growth factor receptor (EGFR) and human EGFR2 in cross-talk activation of
estrogen receptor signaling has led to studies aimed at identifying whether small-molecule tyrosine kinase inhibitors targeted against these receptors give additive or synergistic effects when combined with endocrine agents
Albanito et al., Cancer Res 2007
(Breast Neoplasms...) :
Whether
estrogen receptor alpha (ERalpha) also
contributes to
GPR30/EGFR signaling is less understood
Burga et al., Breast Cancer Res 2011
(Cell Transformation, Neoplastic...) :
Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and
epidermal growth factor receptor inhibition
prevents estrogen receptor negative cancers in BRCA1-mutant mice
Fitzpatrick et al., Cancer Res 1984
(Breast Neoplasms) :
Epidermal growth factor receptors ( EGF-R ) were measured in a series of breast tumors to determine what percentage of breast tumors express EGF-R and whether
EGF-R was
independent of expression of
estrogen receptor and progestin receptor
Sheikh et al., J Cell Biochem 1994
(Breast Neoplasms...) :
Recent studies suggest that the
epidermal growth factor-receptor does not
regulate the
estrogen receptor gene expression ... Whether the
estrogen receptor regulates the
epidermal growth factor-receptor gene expression is not known
deFazio et al., Cell Growth Differ 1997
(Breast Neoplasms) :
Antisense
estrogen receptor RNA expression
increases epidermal growth factor receptor gene expression in breast cancer cells