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CDK3 — JUN
Text-mined interactions from Literome
Cho et al., Cancer Res 2009
(Cell Transformation, Neoplastic) :
Cyclin dependent kinase-3 mediated
c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation ... EGF induced
Cdk3 activation
caused c-Jun phosphorylation at Ser63 and Ser73, resulting in increased AP-1 transactivation
Jalili et al., J Natl Cancer Inst 2012
(MAP Kinase Signaling System...) :
Using a dominant negative approach, in vitro cell proliferation assays, western blots, and flow cytometry showed that MAPK signaling via BRAF ( V600E ) promotes melanoma cell proliferation at G1 through
AP-1 mediated negative regulation of the INK4 family member,
cyclin dependent kinase inhibitor 2C ( CDKN2C ), and the CIP/KIP family member, cyclin dependent kinase inhibitor 1A ( CDKN1A )