◀ Back to IGF1

EGF — IGF1

Text-mined interactions from Literome

Edmondson et al., J Cell Physiol 1999 : Expression of insulin-like growth factor binding protein-3 ( IGFBP-3 ) in human keratinocytes is regulated by EGF and TGFbeta1
Cao et al., Zhonghua Yan Ke Za Zhi 1997 : ( 1 ) EGF , b-FGF, IGF-I significantly increased the DNA 6.6-12.2 times in human RPE cells in comparison with the control, the rank order of potency of the factors being EGF > b-FGF > IGF-I
Wang et al., Mol Cell Biol 1999 : ( i ) Complete Grb10 expression from cDNA with an ecdysone regulated transient expression system stimulated PDGF-BB-, IGF-I , and insulin- but not epidermal growth factor (EGF) induced DNA synthesis in an ecdysone dose-responsive fashion ... ( i ) Complete Grb10 expression from cDNA with an ecdysone regulated transient expression system stimulated PDGF-BB-, IGF-I , and insulin- but not epidermal growth factor (EGF) induced DNA synthesis in an ecdysone dose-responsive fashion
Riedel et al., Oncogene 2000 : ( 1 ) PSM expression from cDNA using an ecdysone regulated transient expression system stimulated PDGF-BB-, IGF-I- , and insulin- but not EGF induced DNA synthesis in an ecdysone dose-responsive fashion ; ( 2 ) Microinjection of the ( dominant negative ) PSM SH2 domain interfered with PDGF-BB- and insulin induced DNA synthesis ; and ( 3 ) A peptide mimetic of the PSM Pro-rich putative SH3 domain binding region interfered with PDGF-BB-, IGF-I-, and insulin- but not with EGF induced DNA synthesis in NIH3T3 fibroblasts
Spicer et al., J Anim Sci 2000 : In the presence of insulin, epidermal growth factor , basic fibroblast growth factor, and estradiol decreased ( P < 0.05 ) IGF-I production below that observed for insulin alone
Arsenijevic et al., J Neurosci 2001 : The newly generated spheres were multipotent, and clonal analysis revealed that EGF or FGF-2, in the presence of IGF-I , acted directly on NSCs
Hallak et al., Hepatology 2002 : In contrast with the inactivity of IGF-I, epidermal growth factor (EGF) induced the tyrosine phosphorylation of the IGF-IR in parallel with EGF receptor phosphorylation ... EGF stimulated the tyrosine phosphorylation of Src, and induced its association with the IGF-IR
Gottlieb et al., J Invest Dermatol 1992 (Psoriasis) : Anthralin treated keratinocytes showed decreased binding of 125I-EGF and 125I-IGF-I to their respective receptors, but EGF receptor binding was inhibited to a greater extent
Barreca et al., Mol Cell Endocrinol 1992 : Effect of epidermal growth factor on insulin-like growth factor-I (IGF-I) and IGF binding protein synthesis by adult rat hepatocytes ... We considered the possibility that IGF-I production by adult rat liver could also be stimulated by epidermal growth factor (EGF) , a peptide known to be involved in liver regeneration ... The stimulation of IGF-I and IGFBP secretion by EGF appears to be dose dependent with a significant increment already evident at 5 nM
Hammerman et al., Miner Electrolyte Metab 1992 : Renal IGF I production is stimulated by growth hormone (GH) and by epidermal growth factor (EGF)
Maruo et al., Steroids 2003 (Leiomyoma...) : Treatment with P4 augmented EGF and Bcl-2 protein expression, but inhibited IGF-I and TNFalpha expression in cultured leiomyoma cells
Abboud et al., J Am Soc Nephrol 1992 (Kidney Diseases) : Mesangial cells may also modulate some of the hemodynamic effects of growth factors, such as the increased renal vascular resistance in response to platelet derived growth factor and epidermal growth factor or the increased RBF and GFR in response to insulin-like growth factor-1
Knowlden et al., Endocrinology 2005 (Breast Neoplasms) : In contrast, epidermal growth factor rapidly induced EGFR, but not IGF-IR , phosphorylation in Tam-R cells
Ayllón et al., Oncogene 2007 : IGF-I could induce PBK expression only in transformed cells, whereas epidermal growth factor could induce PBK in non transformed MCF-10A breast epithelial cells
Eggo et al., Growth Factors 1991 : Thyrotropin inhibits while insulin, epidermal growth factor and tetradecanoyl phorbol acetate stimulate insulin-like growth factor binding protein secretion from sheep thyroid cells
Barnes et al., Clin Cancer Res 2007 (Head and Neck Neoplasms) : Stimulation of head and neck cancer cells with either IGF or EGF resulted in IGF-IR and EGFR heterodimerization, but only IGF caused activating phosphorylation of both receptors
Luo et al., Sci China C Life Sci 2000 : Meanwhile, it was observed that EGF promoted IGF-I mRNA expression, and in preovulatory follicles, IGF-I stimulated LHR mRNA expression
Casillas-Ramírez et al., Endocrinology 2009 (Fatty Liver...) : IGF-I increased egf expression in both liver types
Shankaranarayanan et al., Cancer Cell 2009 (Breast Neoplasms) : IGF/EGF induced IGF receptor 1-mediated MAP kinase blocks rexinoid apoptosis by RXR phosphorylation
Rogers et al., J Clin Invest 1991 : Insulin-like growth factor I gene expression in isolated rat renal collecting duct is stimulated by epidermal growth factor
Wakabayashi et al., J Neurosci Res 2010 (Brain Ischemia...) : In MSC transplanted brain, among many neurotrophic factors, only human insulin-like growth factor 1 (IGF-1) was detected in the core and ischemic border zone at 3 days after MCAO, whereas host cells expressed markedly higher neurotrophic factors ( rat origin ) than control rats, especially vascular endothelial growth factor ( VEGF ) at 3 days and epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) at 7 days after MCAO
Zaouali et al., Liver Transpl 2010 (Disease Models, Animal...) : EGF increased IGF-I , and both additives up-regulated AKT in both liver types
Sakagami et al., J Reprod Dev 2012 : IGF-I induced a dose dependent increase in cell number in both the inner cell mass and the trophectoderm, whereas EGF stimulated proliferation only in the inner cell mass
Mao et al., Theriogenology 2012 : The present study determined the effects of supplementation of maturation medium with porcine follicular fluid ( pFF ; 0, 10 %, 20 %, and 30 % ) on mtDNA copy number and oocyte maturation in experiment 1 ; the effects on epidermal growth factor ( EGF ; 10 ng/mL ), neuregulin 1 ( NRG1 ; 20 ng/mL ), and NRG1 + insulin-like growth factor 1 ( IGF1 ; 100 ng/mL + NRG1 20 ng/mL ), on mtDNA copy number, oocyte maturation, and embryo development after parthenogenic activation in experiment 2 ; and effects on embryo development after in vitro fertilization in experiment 3
Conover et al., J Clin Invest 1989 (Carcinoma, Hepatocellular...) : Insulin, epidermal growth factor , platelet derived growth factor, and progesterone had no effect on IGF binding activity in fibroblast media
Huff et al., Mol Endocrinol 1988 (Breast Neoplasms) : In addition to estrogen, insulin, epidermal growth factor , and transforming growth factor alpha induce both cellular proliferation and IGF-I secretion, while growth inhibitory antiestrogens, transforming growth factor beta, and glucocorticoids have the opposite effect
Dereli et al., Acta Endocrinol (Copenh) 1988 : Besides for glucose, our results demonstrate a role for IGF-I and insulin, but not for EGF , in regulating growth of these cells
Corps et al., FEBS Lett 1988 : Insulin-like growth factor 1 and insulin reduce epidermal growth factor binding to Swiss 3T3 cells by an indirect mechanism that is apparently independent of protein kinase C ... Insulin-like growth factor 1 and insulin reduced the binding of 125I labelled epidermal growth factor ( 125I-EGF ) to Swiss 3T3 cells by 15-20 % at 37 degrees C, but not at 4 degrees C. Scatchard analysis indicated that IGF-1 and insulin affected the higher-affinity component of EGF binding, an effect previously associated with the activation of protein kinase C
Gärtner et al., Acta Endocrinol Suppl (Copenh) 1987 : IGF I production is stimulated in fibroblasts by basal as well as EGF stimulated conditioned medium of thyroid follicles
Hembree et al., Cancer Res 1994 (Uterine Cervical Neoplasms) : In the present study we utilize several human papillomavirus ( HPV ) type 16-immortalized ectocervical epithelial cell lines to investigate the effects of epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) on cell proliferation and the production of IGF binding proteins ( IGFBPs )
Hana et al., Endocrinology 1994 (Endometrial Neoplasms) : EGF , unlike E2, did not increase IGF-I expression but rather resulted in a significant decrease in IGF-I messenger RNA ( mRNA ) levels ... Furthermore, we have demonstrated a clear dissociation of the effects of E2 and EGF on IGF-I expression in this cell line
Lin et al., J Lab Clin Med 1995 (Acute Kidney Injury...) : This study examined the effect of exogenous IGF-1 on the DNA synthesis and EGF receptor (EGF-R) activation in postischemic rat kidneys
Wraight et al., J Invest Dermatol 1995 : Insulin-like growth factor-I and epidermal growth factor regulate insulin-like growth factor binding protein-3 ( IGFBP-3 ) in the human keratinocyte cell line HaCaT
Spicer et al., Mol Cell Endocrinol 1994 : In addition, bFGF ( 5 and 50 ng/ml ) decreased whereas estradiol ( 1 microgram/ml ), FSH ( 10 ng/ml ) and EGF ( 10 and 100 ng/ml ) increased the number of IGF-I receptors in granulosa cells from small follicles
Hana et al., Endocrinology 1994 : Paracrine actions of EGF, which is expressed predominantly in the epithelial cells, on IGF-I expression by stromal cells and paracrine effects of stromal IGF-I on EGF expression in epithelial cells may facilitate the epithelial-stromal interactions, which are thought to be important in E2-induced endometrial proliferation
Rogers et al., Am J Physiol 1994 : For example, GH and EGF each enhances the expression of IGF-I in kidney
Pearl et al., Gynecol Oncol 1993 (Adenocarcinoma...) : The number of KLE cells was increased 2.6-fold by EGF ( 100 ng/ml ), 2.3-fold by IGF-I ( 100 ng/ml ), 2.1-fold by IGF-II ( 100 ng/ml ), and 2.0-fold by insulin ( 1000 ng/ml ) when compared to untreated controls ( P < 0.05 )
Hammerman et al., Am J Physiol 1993 (Diabetes Mellitus...) : In addition to GH, epidermal growth factor (EGF) enhances the renal synthesis of IGF-I
Wosikowski et al., Int J Cancer 1993 (Breast Neoplasms) : We have confirmed this finding and also shown that the new anti-estrogen droloxifene inhibits the proliferation of epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) stimulated MCF-7 cells
Ram et al., Mol Carcinog 1996 (Breast Neoplasms) : By contrast, 21MT-2 cells showed a reduced requirement for IGF but still required EGF to proliferate
Burgaud et al., Exp Cell Res 1996 (Cell Transformation, Viral) : The mutant IGF-I receptors are activated ( tyrosyl phosphorylation of IRS-I ) in response to EGF
Li et al., Exp Gerontol 1996 : We have now investigated the activity of the IGF-I promoter, in response to stimulation of cells by either PDGF or EGF
Vinter-Jensen et al., J Endocrinol 1996 : The effect of epidermal growth factor on circulating levels of IGF and IGF binding proteins in adult Goettingen minipigs
Li et al., Hum Reprod 1997 : Epidermal growth factor (EGF) , transforming growth factor alpha ( TGF alpha ) and insulin-like growth factor-I (IGF-I) stimulated NPC cell proliferation
Bonassar et al., Exp Cell Res 1997 : Given the prominent role of IGF-I in skeletal development and the presence of EGF in the growth plate, this study suggests an important role for interactions between these growth factors in the regulation of skeletal growth
Oguchi et al., Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1997 : Effect of EGF and IGF-I on proliferation, differentiation, and IGF binding protein ( IGFBP ) production of intestinal Caco-2 cells were studied
Putz et al., Cancer Res 1999 (Prostatic Neoplasms) : Moreover, our results demonstrate that selective blockade of the EGF receptor in prostate cancer cells does not only inhibit the action of EGF , but also IGF-I induced activation of the MAPK pathway and the interaction with the PKA pathway