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CDKN1A — ROCK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ROCK2 → CDKN1A (directlyDecreases, CDKN1A Activity)
  Evidence: Whereas the function of CKIs as tumour suppressors is well characterized in the nucleus, they also seem to function in the cytoplasm,where they regulate cytoskeletal functions. This occurs through the modulation of the Rho signalling pathway. This cytoplasmic function could be oncogenic, as inhibition of the Rho pathway can result in increased migratory capacity. Phosphorylation of p21 on Thr145 by protein kinase B (PKB)/Akt48 or Pim1 inhibits the nuclear localization of p21. In the cytoplasm, p...

Text-mined interactions from Literome

Lai et al., Mol Cell Biol 2002 : We also found that only PMA induced proapoptotic cells contained the phosphorylated form of myosin light chain, which is dependent on Rho associated kinase (ROCK) activation, and that expression of a dominant-active form of ROCK suppressed activation of the p21 ( Cip1/Waf1 ) promoter during PMA induction ... Finally, we demonstrated that inhibition of ROCK restores nuclear distribution of phospho-ERK and activation of p21 ( Cip1/Waf1 ) expression
Kamaraju et al., J Biol Chem 2005 (Breast Neoplasms...) : We demonstrate that activation of the p38 MAP kinase pathway is necessary for the full transcriptional activation potential of Smad2/Smad3 by TGF-beta, whereas activity of Rho/ROCK is necessary for both down-regulation of c-Myc protein and up-regulation of p21waf1 protein, directly interfering with p21waf1 transcription
Xiao et al., J Biol Chem 2009 (Prostatic Neoplasms) : In addition, we found that up-regulation of the cell cycle inhibitor p21 ( Cip1 ) is required for PMA induced apoptosis and that inhibitors of ROCK or the cytoskeleton organization prevent p21 ( Cip1 ) induction ... Taken together, our studies implicate ROCK mediated up-regulation of p21 ( Cip1 ) and the cytoskeleton in PKCdelta dependent apoptosis in prostate cancer cells