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CDKN1A — TGFB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → TGFB1 (increases) Petrocca et al., Cancer Cell 2008*
  Evidence: Therefore, we decided to address the role of miR-106b-25 in the presence of TGFb: this cytokine, by inducing the expression of p21 and other antiproliferative molecules, ensures timely coordinated cell-cycle arrest and apoptosis of mature cells in the gastrointestinal tract, thus controlling the physiological turnover of epithelial cells (van den Brink and Offerhaus, 2007).
• OpenBEL Selventa BEL large corpus: CDKN1A → TGFB1 (increases)
  Evidence: FOXO factors form a complex with SMAD transcription factors (which also act as tumor suppressors), resulting in transforming growth factor-b-dependent activation of p21Cip1 and subsequent G1 arrest (Seoane et al., 2004).
• OpenBEL Selventa BEL large corpus: CDKN1A → TGFB1 (increases)
  Evidence: Peripheral blood mononuclear cells of patients with COPD have decreased telomere length, a hallmark of senescing cells in vitro, when compared with normal individuals (225). This observation has been extended to lung cells, as alveolar epithelial and endothelial cells of emphysema patients exhibited enhanced expression of markers of cell senescence including p16Ink4a and p21CIP1/WAF1/Sdi1 and telomere shortening when compared with smokers without emphysema and normal individuals (320).TGF-beta1 ...
• OpenBEL Selventa BEL large corpus: CDKN1A → TGFB1 (increases) Kim et al., J Biol Chem 2002*
  Evidence: p38 alpha and JNK1 phosphorylated p21 in vivo, and both p38 alpha and JNK1 phosphorylated p21 at Ser(130) in vitro.Peptide mapping demonstrated that both TGF-beta 1 and p38 alpha induced phosphorylation of p21 at Ser(130) in vivo, and mutation of Ser(130) to alanine rendered p21 less stable than wild-type p21.
• WikiPathways DNA Damage Response (only ATM dependent): TGFB1 → CDKN1A (activation)

Text-mined interactions from Literome

Kivinen et al., Cell Growth Differ 1999 : We show here that fibroblast growth factor-2 (FGF-2), platelet derived growth factor ( PDGF ), and transforming growth factor-beta1 ( TGF-beta1 ) all induce p21 expression in mouse fibroblasts, but with markedly different kinetics ... We demonstrate that p21 induction by PDGF and TGF-beta1 requires MEK1 ( /2 ) and, additionally, that the TGF-beta1 effect on p21 depends on Ras, whereas the PDGF effect does not
Gray et al., Exp Cell Res 1999 (Carcinoma, Hepatocellular...) : Effects of adding IGF-II or TGFbeta1 to TSA treated cells on p21 induction were examined
Hu et al., J Biol Chem 1999 : The MEK pathway is required for stimulation of p21 ( WAF1/CIP1 ) by transforming growth factor-beta
Ducos et al., J Cell Physiol 2000 : We therefore analyzed whether endogenous TGF-beta1 controls the expression of the p21 ( cip1 ) in the CD34 ( + ) undifferentiated cells using a sensitive in situ hybridization method ... We observed that addition of anti-TGF-beta1 is followed by a rapid decrease in the level of p21 ( cip1 ) mRNA whereas TGF-beta1 enhances p21 ( cip1 ) mRNA expression concurrently with an inhibitory effect on progenitor cell proliferation
Park et al., Cancer Res 2000 (MAP Kinase Signaling System...) : Interestingly, whereas the TGF-beta1 mediated up-regulation of p15INK4B and p21WAF1 transcription was abolished in TSU-Pr1 and V12Ha-Ras transfected DU145, inhibition of the Ras/MAPK pathway restored the TGF-beta1 induction of these genes
Pardali et al., J Biol Chem 2000 : Role of Smad proteins and transcription factor Sp1 in p21 ( Waf1/Cip1 ) regulation by transforming growth factor-beta ... Induction of the endogenous HaCaT p21 gene by TGF-beta1 is further enhanced after overexpression of Smad3 and Smad4, whereas dominant negative mutants of Smad3 and Smad4 and the inhibitory Smad7 all inhibit p21 induction by TGF-beta1 in a dose dependent manner
Iglesias et al., Oncogene 2000 (Carcinoma...) : Smad4 mediates TGF-beta1 induced up-regulation of p21Cip1 and growth arrest in MCA3D cells ... PD098059, a specific inhibitor of MEK, disminishes TGF-beta1 induced p21Cip1 levels in PDV but not in MCA3D cells, suggesting an involvement of Erk in up-regulation of p21Cip1 by TGF-beta1 in PDV cells
Dahler et al., J Invest Dermatol 2001 : When the negative regulator of transforming growth factor beta1 signaling, SMAD7, was overexpressed in keratinocytes it could prevent transforming-growth-factor-beta1 induced activation of the 3TP-Lux and the p21 promoter
Lunz et al., Am J Pathol 2001 (Chronic Disease) : In vitro, nuclear p21 ( WAF1/Cip1 ) expression is increased in large and multinucleated BECs, and is induced by transforming growth factor ( TGF ) -beta ... TGF-beta1 also increases expression of TGF-beta receptor II, causes phosphorylation of SMAD-2 and nuclear translocation of p21 ( WAF1/Cip1 ), which inhibits BEC growth
Sasaki et al., J Biol Chem 2001 : We found that Hgs associated physically with transforming growth factor-beta activated kinase 1 ( TAK1 ) and p21 activated kinase 1 (Pak1) , which mediate the activation of c-Jun N-terminal kinase and serum response factor, respectively, leading to transactivation via the serum-response element and cyclic AMP-response element
Yan et al., J Biol Chem 2002 (Colonic Neoplasms) : Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras dependent, smad independent down-regulation of p21cip1 ... U9 cells expressing DN-N17ras neither proliferated in response to TGFbeta1 nor down-regulated the cdk inhibitor p21cip1 , and TGFbeta1 activation of 3TP-lux in U9 cells was inhibited by DN-N17ras in a dose dependent manner
Park et al., Int J Oncol 2002 (MAP Kinase Signaling System...) : In addition, a combined EB1089 and TGF-beta1 increased p21 and JNK/SAPK activity whereas neither EB1089 nor TGF-beta1 affected p21 and JNK/SAPK activity
Fukuda et al., Virology 2002 (Cell Transformation, Neoplastic...) : TGF-beta 1 activated MAPK ( ERK 1/2 ) and p21 in the TGF-beta 1-susceptible cell line HSC-39 but not in GT38 cells
Roy et al., Circ Res 2003 (Hyperoxia) : The molecular signature response to perceived hyperoxia included ( 1 ) induction of p21 , cyclin D1, cyclin D2, cyclin G1, Fos related antigen-2, and transforming growth factor-beta1, ( 2 ) lowered telomerase activity, and ( 3 ) activation of transforming growth factor-beta1 and p38 mitogen activated protein kinase
Zolota et al., Int J Gastrointest Cancer 2002 (Adenocarcinoma...) : The findings show that TGF-beta1 may be involved in the activation of the cdk inhibitor p21WAF1 in gastric adenocarcinomas, suggesting p53 independent induction of p21 in gastric cells
Gong et al., Cancer Res 2003 (Adenocarcinoma...) : Consequently, p21 induction in early G ( 1 ) is critical for TGF-beta 1 inhibition of CDK2 kinase activity
Ju et al., Cancer Lett 2003 (Stomach Neoplasms) : TGF-beta1 mediated down-regulation of c-Myc and induction of p21CIP1 were observed in SNU-620, but there was no change in SNU-216 in response to TGF-beta1
Lee et al., J Biol Chem 2004 : Stable expression of EID-2 in the TGF-beta1-responsive cell line inhibits endogenous Smad3-Smad4 complex formation and TGF-beta1 induced expression of p21 and p15
Ijichi et al., Oncogene 2004 (Pancreatic Neoplasms) : Smad4 independent regulation of p21/WAF1 by transforming growth factor-beta
Brizzi et al., FASEB J 2004 (Albuminuria...) : We found that, unlike high glucose ( HG ) and Amadori adducts, advanced glycation end products (AGE) and transforming growth factor-beta ( TGF-beta ) induced p21waf expression and accumulation of MC in G0/G1 ... TGF-beta1 blockade inhibited AGE mediated collagen production but only partially affected AGE induced p21waf expression and cell-cycle events, indicating that AGE by binding to AGE receptor ( RAGE ) per se could control MC growth
Miyazaki et al., Cancer Res 2004 (Carcinoma, Hepatocellular...) : In the present study, two new intracellular mediators for the induction of p21/Waf1 by TGF-beta 1 were identified in a human hepatocellular carcinoma cell line ( JHH-5 ) expressing mutant-type p53
Li et al., Biochem Biophys Res Commun 2004 (Pancreatic Neoplasms) : TGF-beta1 induced p21 expression and Smad2 phosphorylation were analyzed by immunoblotting
Pardali et al., J Cell Physiol 2005 : Based on the previously known ability of c-Myc to block p21 expression and epithelial growth arrest in response to TGF-beta1 , we demonstrate that ectopic c-Myc expression can abrogate Smad mediated p21 induction by all TGF-beta and BMP receptors
Wada et al., Kidney Int 2005 : TGF-beta1 increased the protein levels of p21 in p21+/+ podocytes, and this coincided with apoptosis
Kokkinakis et al., Mol Cancer Ther 2005 (Adenocarcinoma...) : Inhibition of cell cycle progression correlates with loss of hyperphosphorylated Rb and up-regulation of p21 via p53 and/or transforming growth factor-beta ( TGF-beta ) activation depending on p53 status
Siegenthaler et al., J Neurosci 2005 : TGFbeta1 selectively increased the expression of p21 in the VZ ... In addition, high p21 expression levels were observed in VZ cells as they exited the cell cycle, and TGFbeta1 increased the number p21 positive cells exiting the cell cycle
Siegenthaler et al., J Neurochem 2005 : Further, ethanol exposure antagonized the anti-proliferative action of TGFbeta1 and blocked TGFbeta1 dependent increases in cell cycle inhibitor p21
Charng et al., Br J Pharmacol 2006 : By serial deletion analysis, the sequence between -74 and -83 bp of the p21 promoter, previously identified as the transforming growth factor-beta ( TGF-beta ) -response element, was found sufficient, where as most of the promoter region 5 ' to -111 bp was found unnecessary for the transcriptional activation of p21 by both TGF-beta1 and Tranilast
Adesina et al., Hum Pathol 2007 (Hepatoblastoma...) : FOXG1 has been implicated in the repression of transforming growth factor beta induced expression of p21cip1 and cytostasis
Hasegawa et al., Cancer Sci 2007 (Biliary Tract Neoplasms) : Restoration of RUNX3 enhances transforming growth factor-beta dependent p21 expression in a biliary tract cancer cell line ... The slightly increased TGF-beta1 induced p21 expression in the control clone was strongly enhanced in the RUNX3 transfected clones, and was accompanied by augmented decreases in the expression of cyclins D1 and E
Kim et al., Arch Pharm Res 2007 : TGF-beta1 induction of p21WAF1/cip1 requires smad independent protein kinase C signaling pathway ... Although it has been demonstrated that p21WAF1/Cip1 could be induced by transforming growth factor-beta1 ( TGF-beta1 ) in a Smad dependent manner, the cross-talk of Smad signaling pathway with other signaling pathways still remains poorly understood ... In this study, we investigated a possible role of protein kinase C ( PKC ) signaling pathway in TGF-beta1 induction of p21WAF1/Cip1 in human keratinocytes HaCaT cells ... Our data show that PKC is required for TGF-beta1 induction of p21WAF1/Cip1 , as evidenced by the fact that specific inhibition of PKC leads to a decrease in p21WAF1/Cip1 protein and mRNA expression induced by TGF-beta1
Yamasaki et al., Am J Respir Cell Mol Biol 2008 (Fibrosis...) : To test this hypothesis we evaluated the effect of TGF-beta(1) on the expression of p21 in the murine lung ... Finally, our studies further demonstrated that TGF-beta(1) induces p21 via a TNF-alpha signaling pathway and that p21 is a negative modulator of TGF-beta(1) induced TNF-alpha expression
Siegenthaler et al., Dev Biol 2008 : Most of these sites do not express Foxg1, a transcription factor that inhibits transforming growth factor ( TGF ) beta dependent upregulation of p21
Lim et al., Mol Cells 2007 : Inhibition of TGF-beta1 activity with TGF-beta 1-specific neutralizing antibody reduced cell cycle arrest as well as expression of the CDK inhibitor p21WAF1
Wang et al., Mol Biol Rep 2009 (Carcinoma, Squamous Cell...) : TGF-beta1 rapidly increased the expression of p15 and p21 in both Tca8113 and Tb cells
Li et al., Chin J Cancer 2008 : SB203580 and WP631 can abrogate excessive proliferation, expressions of p21 ( WAF1/CIP1 ) and PAI-1 induced by gamma rays and TGFbeta1 in HLFs through blocking Smad signal transduction pathway
Yu et al., Invest Ophthalmol Vis Sci 2009 : H ( 2 ) O ( 2 ) and TGF-beta1 and -beta2 markedly enhanced the expression of p21 but downregulated pRb
Pan et al., Zhonghua Xin Xue Guan Bing Za Zhi 2010 : To assess if the modulating effect of platelet derived growth factor (PDGF)-BB on p21 ( WAF1 ) was mediated by upregulating transforming growth factor (TGF)-beta(1) expression in vascular smooth muscle cells ( VSMC )
Nakahata et al., Oncogene 2010 (Leukemia-Lymphoma, Adult T-Cell) : Because the duration of TGF-beta1 induced transcriptional activation of PAI-1 and p21 was shortened in shZEB1 expressing CTLL2 cells, ZEB1 may have a role in enhancing TGF-beta1 signaling by binding not only to Smad3 but also to Smad7 in the nucleus
Ungefroren et al., Curr Cancer Drug Targets 2011 : We show that PP2 and PP1 but not the more specific Src inhibitor SU6656 effectively relieved TGF-b1 induced growth arrest and p21 ( WAF1 ) induction, while basal growth was enhanced by PP2 and PP1, and suppressed by SU6656
Sato et al., Cancer Lett 1997 (Carcinoma, Adenosquamous...) : TGF-beta 1 alone also induced p21WAF1 expression in TYS cells
Datto et al., Mol Cell Biol 1997 : The viral oncoprotein E1A blocks transforming growth factor beta mediated induction of p21/WAF1/Cip1 and p15/INK4B
Sugiyama et al., Biochem Biophys Res Commun 1997 : We investigated the effects of TGF-beta1 on cyclin D1, cyclin A, p21 , p27, and p53 mRNA expressions in primary cultured rat hepatocytes by the reverse-transcription polymerase chain reaction ( RT-PCR ) method ... p21 mRNA expression was greatly induced by TGF-beta1 in a p53 independent mechanism, while p27 mRNA expression was not affected by TGF-beta1
Grau et al., Cancer Res 1997 (Adenocarcinoma...) : Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells
Kamesaki et al., J Immunol 1998 (Lymphoma, B-Cell) : In contrast to epithelial cells, however, TGF-beta1 had little or no effect on the Cdk4 and p21WAF1/Cip1 protein levels in these B cells