Gene interactions and pathways from curated databases and text-mining

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KDR — MMP1

Text-mined interactions from Literome

Sato et al., Ann N Y Acad Sci 2000 : The KDR/Flt-1 heterodimer and the KDR homodimer mediate the expression of Ets-1, MMP-1 , and Flt-1
Adya et al., Cardiovasc Res 2008 : Inhibition of VEGFR2 and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] down-regulated visfatin induced MMP induction
Abdul Muneer et al., Arterioscler Thromb Vasc Biol 2012 (Disease Models, Animal...) : The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP mediated degradation of VEGFR-2 in alcohol ingestion
Mazor et al., J Biol Chem 2013 : Although MMP-1 and VEGFR2 co-exist in many normal and pathophysiological conditions, the effect of MMP-1 on cellular VEGFR2 that can promote the above processes is unknown
dela Paz et al., Biochem Biophys Res Commun 2013 : Early VEGFR2 activation in response to flow is VEGF dependent and mediated by MMP activity ... Finally, we show that flow induced VEGFR2 activation is attenuated in the presence of the broad spectrum matrix metalloproteinase ( MMP ) inhibitor, GM6001