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Maitra et al., Mol Immunol 2009
(Endotoxemia) :
We observed that LPS selectively suppresses the levels of PPARalpha and PGC-1alpha in tissues from WT, but not IRAK-1 ( -/- ) mice
Maitra et al., J Biol Chem 2009
:
On the other hand, we also observed that IRAK-1 is required for LPS mediated suppression of peroxisome proliferator activated receptor alpha and PGC-1alpha , nuclear factors essential for the expression of antioxidative enzymes such as GPX3 and catalase
Sweeney et al., PloS one 2011
(Sepsis) :
Ppargc1a/b activation did not require NF-kß, but did require an interferon response factor ( IRF ) , because neither gene was activated in IRF-3/7 double-knockout mice in sepsis, but both were activated normally in Unc93b1-deficient ( 3d ) mice