Gene interactions and pathways from curated databases and text-mining

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EGR1 — PDGFC

Text-mined interactions from Literome

Midgley et al., J Biol Chem 2004 : Fibroblast growth factor-2 induction of platelet derived growth factor-C chain transcription in vascular smooth muscle cells is ERK dependent but not JNK dependent and mediated by Egr-1 ... These findings thus demonstrate that PDGF-C transcription, activated by FGF-2, is mediated by Egr-1 and its upstream kinase ERK
Sanchez-Guerrero et al., Nucleic Acids Res 2008 : Angiotensin II induction of PDGF-C expression is mediated by AT1 receptor dependent Egr-1 transactivation ... ATII induction of PDGF-C transcription is mediated by the angiotensin type 1 receptor (AT1R) and Egr-1 activation through this upstream element