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MOK — PTGS2

Text-mined interactions from Literome

Bianchi et al., J Leukoc Biol 2007 : We show here that S100B up-regulates cyclo-oxygenase-2 expression in microglia in a RAGE dependent manner in the absence of cofactors through independent stimulation of a Cdc42-Rac1-JNK pathway and a Ras-Rac1-NF-kappaB pathway
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1