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LEPR — STAT3

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by PTP1B: STAT3 (STAT3) → Jak2/Leptin Receptor/Leptin complex (JAK2-LEPR-LEP) (modification, collaborate)
  Vaisse et al., Nat Genet 1996*
  Evidence: physical interaction, other species
• NCI Pathway Database Signaling events mediated by PTP1B: STAT3 (dimer ) complex (STAT3) → Jak2/Leptin Receptor complex (JAK2-LEPR) (transcription, activates)
  Bjørbaek et al., J Biol Chem 1999
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: STAT3 → LEPR (indirect_complex) Bjørbaek et al., J Biol Chem 1997
• Reactome Reaction: STAT3 → LEPR (reaction) Bjørbaek et al., J Biol Chem 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: STAT3 — LEPR (in vivo) Chen et al., Cell 1996*
• IRef Ophid Interaction: STAT3 — LEPR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Papathanassoglou et al., J Immunol 2006 : Leptin binding to ObR results in increased STAT-3 activation in T cells, with a different activation pattern in resting vs anti-CD3 Ab stimulated T cells
Nair et al., Am J Respir Cell Mol Biol 2008 : Leptin receptor expression and activation of STAT-3 , Src kinase, Suppressor of Cytokine Signaling-3 ( SOCS-3 ), and COX were evaluated by Western blotting and PCR
Gove et al., J Leukoc Biol 2009 (Colitis...) : Role of leptin receptor induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice
Mancuso et al., J Immunol 2012 (Klebsiella Infections...) : We recently reported that disruption of leptin receptor mediated STAT3 activation augmented host defense against pneumococcal pneumonia
Wu et al., J Cell Biochem 2013 (Liver Cirrhosis) : Our results provide a new finding that HCVcp induced ObR dependent Janus Kinase (JAK) 2-STAT3 , AMPKa, and AKT signaling pathways and modulated downstream fibrogenetic gene expression in HSCs. J. Cell
Leifheit-Nestler et al., Journal of translational medicine 2013 : Our findings suggest that hearts from obese mice continue to respond to elevated circulating or cardiac leptin, which may mediate cardioprotection via LepR induced STAT3 activation, whereas signals distinct from LepR-Tyr1138 promote cardiac hypertrophy
Nakashima et al., FEBS Lett 1997 : Stimulation of either a long form of OB-R or gp130 led to tyrosine phosphorylation of STAT3 , whereas stimulation of the truncated form of OB-R that is predominantly expressed in dbldb mice failed to do so