Galmozzi et al., J Cell Physiol 2004
(Carcinoma...) :
Both the increase in c-Myc protein levels and P2L enhanced translational activity were inhibited by the PI3K inhibitor wortmannin
Kumar et al., Mol Cell Biol 2006
:
Inhibition of late-G ( 1 ) PI3K activity results in low c-Myc and cyclin A expression, impaired Cdk2 activity, and reduced loading of MCM2 ( minichromosome maintenance protein ) onto chromatin
Shepherd et al., Leukemia 2013
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response