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NGF — TNF
Text-mined interactions from Literome
Marshall et al., J Immunol 1999
:
We have observed that
NGF at doses as low as 10 ng/ml will induce IL-6 production and
inhibit TNF-alpha release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor
Aloe et al., Brain Res 1999
(Nervous System Diseases) :
In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system ( CNS ), one characterized by reactive gliosis, inflammatory demyelination and neurological deficits ( Tg6074 ) the other showing no neurological or phenotypical alterations ( TgK3 ) to investigate the
effect of
TNF-alpha on brain
nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) levels and learning abilities
Nagatsu et al., J Neural Transm Suppl 2000
(Parkinson Disease...) :
In experimental animal models of PD, IL-1beta level was increased and
NGF one decreased in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) -induced parkinsonian mice, and
TNF-alpha level was
increased in the substantia nigra and striatum of the 6-hydroxydopamine ( 6OHDA ) -injected side of hemiparkinsonian rats
Barouch et al., J Leukoc Biol 2001
(MAP Kinase Signaling System) :
In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the
effect of
NGF on
tumor necrosis factor (TNF)-alpha production ... The
induction of
TNF-alpha production by
NGF was blocked by K252a, an inhibitor of the TrkA receptor
Manni et al., Clin Exp Rheumatol 2003
(Inflammation...) :
Both interleukin-1-beta (IL-1 beta) and
TNF-alpha , but not CCK-8
promote NGF synthesis and release from OA cells
Golan et al., Cereb Cortex 2004
:
Moreover, lack of
TNFalpha increased the expression of
nerve growth factor (NGF) , but not brain derived neurotrophic factor (BDNF), following performance of the learning task
Ma et al., Infect Immun 2004
:
Our experiments were designed to explore the mechanism of effect of L. reuteri in the human epithelial cell lines T84 and HT29 on cytokine and
NGF synthesis and IL-8
response to
tumor necrosis factor alpha (TNF-alpha)
Bläsing et al., Arch Dermatol Res 2005
:
By immunohistology, IFNgamma, IL-1beta, and
TNF-alpha as well as a cocktail of all three cytokines
increased NGF immunoreactivity ( IR ) in the proximal outer root sheath and hair matrix of anagen VI pelage hair follicles
Caroleo et al., Alcohol 2004
:
Because NGF has been reported to affect the synthesis of proinflammatory cytokines, we also evaluated whether the production of
tumor necrosis factor-alpha would be
affected by ethanol mediated changes in
NGF synthesis
Manna et al., J Cell Physiol 2006
:
In this report we provide evidences that oleandrin, a cardiac glycoside potentially inhibited IL-8-, formyl peptide ( FMLP ) -, EGF-, or
nerve growth factor (NGF)- , but not IL-1- or
TNF induced NF-kappaB
activation in macrophages
Wang et al., Pflugers Arch 2006
(Inflammation) :
In contrast,
TNF-alpha induced rapid and substantial increases in expression of the genes encoding IL-6, MCP-1,
NGF and TNF-alpha itself ; IL-6 and TNF-alpha mRNA levels peaked at 2 h with 75-fold and 600-fold increases, respectively ... The adipokine secretion pattern largely paralleled cellular mRNA levels ; IL-6 ( transiently ), MCP-1,
NGF and VEGF release were
stimulated by
TNF-alpha , with an accelerating rate of MCP-1 secretion over 24 h. TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes, with highly gene-specific responses
Gölz et al., Eur J Neurosci 2006
:
TNFalpha inhibited NT-3-, NT-3 +
NGF- , NT-4 + NGF- and NT-3 + NT-4 + NGF induced outgrowth
Abe et al., Spine (Phila Pa 1976) 2007
(Cadaver) :
The
effects of interleukin-1beta (IL-1beta) and
tumor necrosis factor-alpha (TNF-alpha) on
NGF production and mRNA expression of NGF by IVD cells were examined ... IL-1beta and
TNF-alpha up-regulated the
NGF mRNA expression and the secretion of NGF protein into the media
Jiang et al., J Immunol 2007
:
NGF could markedly
promote LPS induced expression of HLA-DR, CD40, CD80, CD83, CD86, CCR7, secretion of IL-12p40 and proinflammatory cytokines IL-1, IL-6,
TNF-alpha , and the T cell stimulating capacity of MoDCs, indicating that NGF can promote LPS induced DC maturation
Takei et al., Mol Biol Cell 2008
(Neuroblastoma...) :
We find that
NGF can
induce TNF-alpha synthesis through the nuclear factor-kappaB transcription factor ... Thus, NGF and
NGF induced
TNF-alpha cooperate to activate Akt, promoting survival of normal neural cells ... However, the
NGF induced
TNF-alpha suppresses Erk activation by NGF, blocking NGF induced differentiation of neuroblastoma cells
Smith et al., Biochem Biophys Res Commun 1991
:
T2 binding of
TNF is not
inhibited by
nerve growth factor , although the nerve growth factor receptor is also a member of the same family, nor by nine other recombinant cytokines
Taishi et al., Brain Res 2008
:
IL1beta icv, but not
TNFalpha ,
increased NGF mRNA levels in both these areas
Raychaudhuri et al., Scand J Rheumatol 2009
(Arthritis...) :
FACS studies showed that unstimulated FLS expressed low levels of NGF and the high-affinity NGF-tyrosine kinase receptor TrkA, and
TNFalpha and IL-1beta
increased NGF and TrkA expression in FLS
Steiner et al., Am J Physiol 1991
:
Interleukin-1 beta and
tumor necrosis factor-alpha synergistically
stimulate nerve growth factor synthesis in rat mesangial cells
Lebrun-Julien et al., Proc Natl Acad Sci U S A 2010
:
Consistent with this, we show that
proNGF induced robust expression of
tumor necrosis factor alpha (TNFalpha) in Müller cells and that genetic or biochemical ablation of TNFalpha blocked proNGF induced death of retinal neurons ... Mice rendered null for p75 ( NTR ), its coreceptor sortilin, or the adaptor protein NRAGE were defective in
proNGF induced glial
TNFalpha production and did not undergo proNGF induced retinal ganglion cell death
Lee et al., J Orthop Res 2011
(Intervertebral Disc Degeneration...) :
In this study, we investigated the
effects of inflammatory cytokines, IL-1ß, and
TNF-a , on the expression of an angiogenic factor, vascular endothelial growth factor ( VEGF ), and neurotrophic factors,
nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), in human IVD degeneration ... IL-1ß and
TNF-a stimulated the gene expression of VEGF,
NGF , and BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues
Gadient et al., Neurosci Lett 1990
:
Interleukin-1 beta and
tumor necrosis factor-alpha synergistically
stimulate nerve growth factor (NGF) release from cultured rat astrocytes ... To examine regulation of NGF gene expression with respect to neural trauma we examined the
effects of interleukin-1 beta (IL-1 beta) and
tumor necrosis factor-alpha (TNF-alpha) on
NGF production in cultures of rat astroglial cells
Hsieh et al., J Comp Neurol 2012
(Neuralgia) :
We investigated the effects of low-level laser on the accumulation of HIF-1a,
tumor necrosis factor-a (TNF-a), and interleukin-1ß (IL-1ß) in controlling neuropathic pain, as well as on the
activation of vascular endothelial growth factor ( VEGF ) and
nerve growth factor (NGF) in promoting functional recovery in a rat CCI model
Al-Gayyar et al., PloS one 2013
(Diabetes Mellitus, Experimental...) :
While
proNGF induced
TNF-a expression in vivo, it selectively activated RhoA in primary RGC cultures and RGC-5 cell line
Patterson et al., Endocrinology 1994
:
In addition, GH releasing hormone,
tumor necrosis factor-alpha , basic fibroblast growth factor, and forskolin all
caused an inhibition of
NGF secretion below basal levels
Hattori et al., J Biol Chem 1993
:
Tumor necrosis factor stimulates the synthesis and secretion of biologically active
nerve growth factor in non-neuronal cells ...
TNF stimulates the synthesis and secretion of
NGF also in other cells such as human glioblastoma cells
Plüss et al., Biochem J 1995
:
We found that co-stimulation of rat glomerular mesangial cells with platelet derived growth factor ( PGDF-BB ) and IL-1 beta/TNF-alpha significantly augments the IL-1
beta/TNF-alpha induced
NGF mRNA levels and NGF synthesis ... In contrast, preincubation with PDGF-BB drastically reduces
NGF gene expression and NGF protein synthesis in
response to IL-1
beta/TNF-alpha stimulation
Hattorl et al., Biochem Mol Biol Int 1996
:
Although TGF-beta 1 and Activin A stimulated NGF production in Swiss 3T3 cells, they antagonized the stimulatory
effect of
TNF on fibroblast
NGF production when used in combination
Brodie et al., FEBS Lett 1996
:
Moreover, INF-gamma completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the
induction of
NGF by
TNF-alpha
Galve-Roperh et al., J Neurochem 1998
:
Evidence for the lack of involvement of sphingomyelin hydrolysis in the
tumor necrosis factor induced secretion of
nerve growth factor in primary astrocyte cultures ... Because ceramide is also able to induce NGF secretion and because TNF alpha is a known agonist of the sphingomyelin ( SPM ) -ceramide pathway, we investigated whether the
TNF alpha induced
NGF secretion by primary astrocytes is mediated by ceramide ... Altogether, our data strongly suggest that
TNF alpha mediated up-regulation of
NGF occurs independently of ceramide generation
Manni et al., Rheumatol Int 1998
(Arthritis, Experimental) :
Role of IL-1 beta and
TNF-alpha in the regulation of
NGF in experimentally induced arthritis in mice ... The aim of this study was to investigate the
effects of IL-1 beta and
TNF-alpha on
NGF levels in the knee joint in experimentally induced arthritis in adult mice ... Out data showed that IL-1 beta, but not
TNF-alpha ,
induces an increase in
NGF levels, while concomitant injection of both cytokines enhances the effect of IL-1 beta on NGF presence