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Whittaker et al., J Immunol 2000
:
Blocking COX-2 reduces I-MDC secretion of IL-12p40, whereas it increases IL-12p40 and p70 production by maturing MDC
Schwacha et al., Am J Physiol Cell Physiol 2002
(Bacterial Infections...) :
Thus elevated Mphi COX-2 activity, independent of IL-10, suppresses Mphi IL-12 production after thermal injury and may play an important role in the observed immunosuppression under such conditions
Muthian et al., J Clin Immunol 2006
(Demyelinating Diseases...) :
Further analyses showed that the COX-2 inhibitors reduced neural antigen induced IL-12 production, T cell proliferation and Th1 differentiation ex vivo and in vitro