Gene interactions and pathways from curated databases and text-mining

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APOB — APOC2

Pathways - manually collected, often from reviews:

  • Reactome Reaction: APOB → APOC2 (indirect_complex)
  • Reactome Reaction: APOB → APOC2 (reaction)

Text-mined interactions from Literome

Black et al., Biochem J 1992 : Apo B may be specifically down-regulated by the chylomicron secretory blockade induced by Pluronic L-81
Huard et al., Int J Biochem Cell Biol 2005 (Carcinoma, Hepatocellular) : Different levels of secreted apoC-II or apoC-III had little effect on LDL and HDL protein degradation by HepG2 cells
Rifai et al., Arch Pathol Lab Med 1986 (Coronary Disease) : Apolipoprotein AI activates the lecithin cholesterol acyltransferase, apolipoprotein CII and CIII regulate the lipoprotein lipase, and apolipoprotein B-100 , B-48, and E control the cholesterol uptake into hepatic and extrahepatic cells
Levy et al., FEBS Lett 1996 : Adding insulin ( 3 mU ) to the serum-free medium of cultured jejunal explants from human fetuses ( 17-20 weeks ) reduced triglyceride and chylomicron production and inhibited apo B-48 and apo B-100 secretion
Taggart et al., Diabet Med 1997 (Diabetes Mellitus, Type 2) : The postprandial chylomicron apolipoprotein B48 response of both diabetic and control subjects to the cholesterol meal was less than to the cholesterol-free meal ( p < 0.001 )